Ferroptosis meets microRNAs: A new frontier in anti-cancer therapy

Ferroptosis is an iron-dependent lipid peroxidation-mediated cell death. It is distinct from other types of cellular death and is recognized as a potential target for cancer therapy. This review discusses the mechanisms of ferroptosis, including its induction and inhibition pathways, its role in lipid metabolism, and its connection to various signaling pathways. We also explored the relationship between microRNAs and ferroptosis, highlighting the potential role of miRNAs targeting genes involved in ferroptosis. Role of miRNAs in metabolic reprogramming during carcinogenesis is well documented. We have discussed the role of miRNAs regulating expression of genes involved in iron metabolism, lipid metabolism, and redox metabolism which are associated with regulation of ferroptosis. In conclusion, we addressed various opportunities and challenges identified in ferroptosis research and its clinical implementation stressing the necessity of customized treatment plans based on each patient's unique vulnerability to the disease. Our article provides a complete overview of microRNAs and ferroptosis, with possible implications for cancer therapy. [Display omitted] •Ferroptosis driven lipid peroxidation offers unique treatment strategy by exploiting cancer cells metabolic state.•miRNAs regulate ferroptosis by targeting system xc⁻ and p53 signaling pathway.•miRNAs can either promote or inhibit ferroptosis making them valuable as cancer biomarkers and therapeutic agents.•Targeted miRNA delivery in tumor tissue to promote ferroptosis could advance cancer treatments.