Organophosphate Insecticide Malathion Induces Alzheimer’s Disease-Like Cognitive Impairment in Mice: Evidence of the Microbiota-Gut-Brain Axis

Evidence suggests that exposure to organophosphate pesticides increases the risk of neurodegenerative diseases, but the mechanisms remain unclear. This study investigated the effects of malathion on Alzheimer’s disease (AD)-like symptoms at environmentally relevant concentrations using wild-type (WT...

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Veröffentlicht in:	Environmental science & technology 2024-12, Vol.58 (50), p.21966-21977
Hauptverfasser:	Cui, Jingna, Xiao, Shouchun, Cao, Yue, Zhang, Yaru, Yang, Jiaxing, Zheng, Li, Zhao, Fanrong, Liu, Xueke, Liu, Donghui, Zhou, Zhiqiang, Wang, Peng
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease Alzheimer's disease Animal models Animals Brain Brain-Gut Axis Cognitive ability Cognitive Dysfunction - chemically induced Disease Disruption Dysbacteriosis Ecotoxicology and Public Health Exposure Gastrointestinal Microbiome - drug effects Health risks Hippocampus Impairment Indoles Inflammation Insecticides Insecticides - toxicity Intestinal microflora Malathion Malathion - toxicity Metabolism Metabolites Mice Mice, Transgenic Microbiota Microorganisms mRNA Neurodegenerative diseases Neurotoxicity Organophosphates Organophosphorus pesticides Pesticides Presenilin 1 Protein turnover Quinolinic acid Serotonin Signs and symptoms Transgenic mice Tryptophan β-Amyloid
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