Adolescents and young adults with sickle cell disease exhibit accelerated aging with elevated T-cell p16INK4a expression

People living with sickle cell disease (SCD) experience complications indicative of an accelerated aging phenotype typified by early decline in physical function and increased risk for age-related conditions. Cellular senescence, measured by expression of p16INK4a in peripheral T-lymphocytes, is rec...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2024-11, Vol.16 (21), p.13225
Hauptverfasser:	Wilson, Samuel R., Mitin, Natalia, Miller, Vanessa L. Ayer, Smitherman, Andrew B., Carden, Marcus A.
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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