Lysosomal damage triggers a p38 MAPK-dependent phosphorylation cascade to promote lysophagy via the small heat shock protein HSP27

Maintenance of lysosomal integrity is essential for cell viability. Upon injury, lysosomes may be targeted for degradation via a selective form of autophagy known as lysophagy. The engulfment of a damaged lysosome by an autophagosome is mediated by the recruitment of adaptor proteins, including SQST...

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Veröffentlicht in:	Current biology 2024-11
Hauptverfasser:	Gallagher, Elizabeth R., Oloko, Peace T., Fitch, Tessa C., Brown, Elizabeth M., Spruce, Lynn A., Holzbaur, Erika L.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	HSP27 lysophagy oligomers p38 MAPK phase separation phosphorylation SQSTM1/p62
Online-Zugang:	Volltext
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