Drug-induced cholestasis (DIC) predictions based on in vitro inhibition of major bile acid clearance mechanisms

Drug-induced cholestasis (DIC) is recognized as a major safety concern in drug development, as it represents one of the three types of drug-induced liver injury (DILI). Cholestasis is characterized by the disruption of bile flow, leading to intrahepatic accumulation of toxic bile acids. Bile acid re...

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Veröffentlicht in:	Archives of toxicology 2025, Vol.99 (1), p.377-391
Hauptverfasser:	Kastrinou-Lampou, Vlasia, Rodríguez-Pérez, Raquel, Poller, Birk, Huth, Felix, Schadt, Heiko S., Kullak-Ublick, Gerd A., Arand, Michael, Camenisch, Gian
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Bile Bile acids Bile Acids and Salts - metabolism Biomedical and Life Sciences Biomedicine Chemical and Drug Induced Liver Injury - etiology Chemical and Drug Induced Liver Injury - metabolism Cholestasis Cholestasis - chemically induced Cholestasis - metabolism Clearances Cytochrome P-450 CYP3A - metabolism Drug development Drug metabolism Drugs Efflux Environmental Health Gallbladder diseases Homeostasis Humans Liver-Specific Organic Anion Transporter 1 - antagonists & inhibitors Liver-Specific Organic Anion Transporter 1 - metabolism Models, Biological Occupational Medicine/Industrial Medicine Organ Toxicity and Mechanisms Performance enhancement Pharmacology/Toxicology Prediction models Predictions Synergistic effect
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