Warmblood fragile foal syndrome: Pregnancy loss in Warmblood mares
Fragile foal syndrome (FFS) or warmblood FFS Type 1 (WFFS) is a recessive, autosomal, hereditary, genetic defect causing late abortions, stillbirths and non-viable foals. Whether early pregnancy losses occur is unknown. To investigate how WFFS affects pregnancies and whether early pregnancy losses o...
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| creator | Kehlbeck, A Blanco, M Venner, Monica Freise, Fritjof Gunreben, B Sieme, Harald |
| description | Fragile foal syndrome (FFS) or warmblood FFS Type 1 (WFFS) is a recessive, autosomal, hereditary, genetic defect causing late abortions, stillbirths and non-viable foals. Whether early pregnancy losses occur is unknown.
To investigate how WFFS affects pregnancies and whether early pregnancy losses occur in WFFS matings and if there is a difference in pregnancy success between matings where both parents were allele carriers and those where only mare or stallion were WFFS carriers.
Retrospective cohort study.
Breeding records from a Warmblood stud farm were evaluated (2016-2019) and 2682 cycles of 177 mares analysed. Matings were assigned to four study groups, depending on the WFFS carrier status of the mare and stallion: N/WFFS × N/WFFS (n = 46), N/WFFS (mares) × N/N (n = 511), N/N × N/WFFS (stallions) (n = 191) and N/N × N/N (n = 2149).
There were no differences in pregnancy rates between matings with only one WFFS carrier and those with non-carriers. When comparing N/WFFS × N/WFFS matings to those with only one or no WFFS-carrier, there were no increased pregnancy losses in the embryonic phase (day |
| doi_str_mv | 10.1111/evj.14435 |
| format | Article |
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To investigate how WFFS affects pregnancies and whether early pregnancy losses occur in WFFS matings and if there is a difference in pregnancy success between matings where both parents were allele carriers and those where only mare or stallion were WFFS carriers.
Retrospective cohort study.
Breeding records from a Warmblood stud farm were evaluated (2016-2019) and 2682 cycles of 177 mares analysed. Matings were assigned to four study groups, depending on the WFFS carrier status of the mare and stallion: N/WFFS × N/WFFS (n = 46), N/WFFS (mares) × N/N (n = 511), N/N × N/WFFS (stallions) (n = 191) and N/N × N/N (n = 2149).
There were no differences in pregnancy rates between matings with only one WFFS carrier and those with non-carriers. When comparing N/WFFS × N/WFFS matings to those with only one or no WFFS-carrier, there were no increased pregnancy losses in the embryonic phase (day <42). By contrast, the N/WFFS × N/WFFS group had significantly more abortions (53.8%) than the other three study groups (7.9-9.2%; adjusted p < 0.0001). The higher losses were evenly distributed between the early (D42-150: 22.7% losses, n = 5) and late (D150-300: 29.4% losses, n = 5) foetal phase. The live foal rate per pregnancy for N/WFFS × N/WFFS matings was lowest (34.5%) and differed significantly (other groups 81%-84%; adjusted p < 0.0001); the peri- and postnatal mortality was higher (25%) compared with the other study groups (2.6%-3%).
Low sample size in N/WWFS × N/WFFS matings, unbalanced study design, outcomes are descriptive, all mares from one stud farm.
The mating of two WFFS carriers may lead to increased risks of pregnancy and foal loss.</description><identifier>ISSN: 0425-1644</identifier><identifier>ISSN: 2042-3306</identifier><identifier>EISSN: 2042-3306</identifier><identifier>DOI: 10.1111/evj.14435</identifier><identifier>PMID: 39539185</identifier><language>eng</language><publisher>United States</publisher><ispartof>Equine veterinary journal, 2024-11</ispartof><rights>2024 EVJ Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c210t-45815a670ca400420d02d89716586b1587cc349a4710a229b8d31a73d3c283853</cites><orcidid>0000-0002-1062-9406 ; 0000-0001-9658-8790</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39539185$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kehlbeck, A</creatorcontrib><creatorcontrib>Blanco, M</creatorcontrib><creatorcontrib>Venner, Monica</creatorcontrib><creatorcontrib>Freise, Fritjof</creatorcontrib><creatorcontrib>Gunreben, B</creatorcontrib><creatorcontrib>Sieme, Harald</creatorcontrib><title>Warmblood fragile foal syndrome: Pregnancy loss in Warmblood mares</title><title>Equine veterinary journal</title><addtitle>Equine Vet J</addtitle><description>Fragile foal syndrome (FFS) or warmblood FFS Type 1 (WFFS) is a recessive, autosomal, hereditary, genetic defect causing late abortions, stillbirths and non-viable foals. Whether early pregnancy losses occur is unknown.
To investigate how WFFS affects pregnancies and whether early pregnancy losses occur in WFFS matings and if there is a difference in pregnancy success between matings where both parents were allele carriers and those where only mare or stallion were WFFS carriers.
Retrospective cohort study.
Breeding records from a Warmblood stud farm were evaluated (2016-2019) and 2682 cycles of 177 mares analysed. Matings were assigned to four study groups, depending on the WFFS carrier status of the mare and stallion: N/WFFS × N/WFFS (n = 46), N/WFFS (mares) × N/N (n = 511), N/N × N/WFFS (stallions) (n = 191) and N/N × N/N (n = 2149).
There were no differences in pregnancy rates between matings with only one WFFS carrier and those with non-carriers. When comparing N/WFFS × N/WFFS matings to those with only one or no WFFS-carrier, there were no increased pregnancy losses in the embryonic phase (day <42). By contrast, the N/WFFS × N/WFFS group had significantly more abortions (53.8%) than the other three study groups (7.9-9.2%; adjusted p < 0.0001). The higher losses were evenly distributed between the early (D42-150: 22.7% losses, n = 5) and late (D150-300: 29.4% losses, n = 5) foetal phase. The live foal rate per pregnancy for N/WFFS × N/WFFS matings was lowest (34.5%) and differed significantly (other groups 81%-84%; adjusted p < 0.0001); the peri- and postnatal mortality was higher (25%) compared with the other study groups (2.6%-3%).
Low sample size in N/WWFS × N/WFFS matings, unbalanced study design, outcomes are descriptive, all mares from one stud farm.
The mating of two WFFS carriers may lead to increased risks of pregnancy and foal loss.</description><issn>0425-1644</issn><issn>2042-3306</issn><issn>2042-3306</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNpFkD1PwzAQhi0EoqUw8AeQRxhSfD47cdig4kuqBAOIMXJsp0rlJMWmSP33GFrglrvhuVevHkJOgU0hzaX7XE5BCJR7ZMyZ4Bkiy_fJOJ0yg1yIETmKcckYIhf8kIywlFiCkmNy86ZDV_thsLQJetF6R5tBexo3vQ1D567oc3CLXvdmQ_0QI217-v_S6eDiMTlotI_uZLcn5PXu9mX2kM2f7h9n1_PMcGAfmZAKpM4LZrRgqRmzjFtVFpBLldcgVWEMilKLApjmvKyVRdAFWjRcoZI4Iefb3FUY3tcuflRdG43zXvduWMcKgSvFAVSZ0IstakLqHFxTrUKbym4qYNW3siopq36UJfZsF7uuO2f_yF9H-AUxYWRs</recordid><startdate>20241114</startdate><enddate>20241114</enddate><creator>Kehlbeck, A</creator><creator>Blanco, M</creator><creator>Venner, Monica</creator><creator>Freise, Fritjof</creator><creator>Gunreben, B</creator><creator>Sieme, Harald</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-1062-9406</orcidid><orcidid>https://orcid.org/0000-0001-9658-8790</orcidid></search><sort><creationdate>20241114</creationdate><title>Warmblood fragile foal syndrome: Pregnancy loss in Warmblood mares</title><author>Kehlbeck, A ; Blanco, M ; Venner, Monica ; Freise, Fritjof ; Gunreben, B ; Sieme, Harald</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c210t-45815a670ca400420d02d89716586b1587cc349a4710a229b8d31a73d3c283853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kehlbeck, A</creatorcontrib><creatorcontrib>Blanco, M</creatorcontrib><creatorcontrib>Venner, Monica</creatorcontrib><creatorcontrib>Freise, Fritjof</creatorcontrib><creatorcontrib>Gunreben, B</creatorcontrib><creatorcontrib>Sieme, Harald</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Equine veterinary journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kehlbeck, A</au><au>Blanco, M</au><au>Venner, Monica</au><au>Freise, Fritjof</au><au>Gunreben, B</au><au>Sieme, Harald</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Warmblood fragile foal syndrome: Pregnancy loss in Warmblood mares</atitle><jtitle>Equine veterinary journal</jtitle><addtitle>Equine Vet J</addtitle><date>2024-11-14</date><risdate>2024</risdate><issn>0425-1644</issn><issn>2042-3306</issn><eissn>2042-3306</eissn><abstract>Fragile foal syndrome (FFS) or warmblood FFS Type 1 (WFFS) is a recessive, autosomal, hereditary, genetic defect causing late abortions, stillbirths and non-viable foals. Whether early pregnancy losses occur is unknown.
To investigate how WFFS affects pregnancies and whether early pregnancy losses occur in WFFS matings and if there is a difference in pregnancy success between matings where both parents were allele carriers and those where only mare or stallion were WFFS carriers.
Retrospective cohort study.
Breeding records from a Warmblood stud farm were evaluated (2016-2019) and 2682 cycles of 177 mares analysed. Matings were assigned to four study groups, depending on the WFFS carrier status of the mare and stallion: N/WFFS × N/WFFS (n = 46), N/WFFS (mares) × N/N (n = 511), N/N × N/WFFS (stallions) (n = 191) and N/N × N/N (n = 2149).
There were no differences in pregnancy rates between matings with only one WFFS carrier and those with non-carriers. When comparing N/WFFS × N/WFFS matings to those with only one or no WFFS-carrier, there were no increased pregnancy losses in the embryonic phase (day <42). By contrast, the N/WFFS × N/WFFS group had significantly more abortions (53.8%) than the other three study groups (7.9-9.2%; adjusted p < 0.0001). The higher losses were evenly distributed between the early (D42-150: 22.7% losses, n = 5) and late (D150-300: 29.4% losses, n = 5) foetal phase. The live foal rate per pregnancy for N/WFFS × N/WFFS matings was lowest (34.5%) and differed significantly (other groups 81%-84%; adjusted p < 0.0001); the peri- and postnatal mortality was higher (25%) compared with the other study groups (2.6%-3%).
Low sample size in N/WWFS × N/WFFS matings, unbalanced study design, outcomes are descriptive, all mares from one stud farm.
The mating of two WFFS carriers may lead to increased risks of pregnancy and foal loss.</abstract><cop>United States</cop><pmid>39539185</pmid><doi>10.1111/evj.14435</doi><orcidid>https://orcid.org/0000-0002-1062-9406</orcidid><orcidid>https://orcid.org/0000-0001-9658-8790</orcidid><oa>free_for_read</oa></addata></record> |
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| title | Warmblood fragile foal syndrome: Pregnancy loss in Warmblood mares |
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