A glucose-rich heteropolysaccharide from Marsdenia tenacissima (Roxb.) Wight et Arn. and its zinc-modified complex enhance immunoregulation by regulating TLR4-Myd88-NF-κB pathway

A previously unreported immunological polysaccharide (MTP70–1) was obtained from Marsdenia tenacissima (Roxb.) Wight et Arn. MTP70–1 (2738 Da) is a heteropolysaccharide that mainly consists of (1 → 5)-linked-L-Araf, t-D-Glcp, (1 → 3,5)-linked-L-Araf, (1 → 4)-linked-D-Galp, (1 → 6)-linked-D-Glcp, and...

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Veröffentlicht in:	International journal of biological macromolecules 2024-12, Vol.283 (Pt 1), p.137529, Article 137529
Hauptverfasser:	Li, Chong, Wang, Kai, Wang, Cancan, Li, Junhao, Zhang, Qian, Song, Lijun, Wu, Zhongnan, Zhang, Shaojie
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cytokines - metabolism Glucose - metabolism Immunoregulatory activity Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Marsdenia - chemistry Marsdenia tenacissima (Roxb.) Wight et Arn Mice Myeloid Differentiation Factor 88 - metabolism NF-kappa B - metabolism NF-κB pathway Phagocytosis - drug effects Polysaccharides - chemistry Polysaccharides - pharmacology RAW 264.7 Cells Signal Transduction - drug effects Toll-Like Receptor 4 - metabolism Zebrafish Zebrafish - immunology Zinc - chemistry Zinc modification
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