Retinal vascular events and relationship to CANCER development
Central retinal vein occlusion (CRVO) is a frequent and clinically relevant vascular pathology. The main risk factors are the same as systemic cardiovascular risk factors, but recently other significant risk factors have been studied. The aim of this study is to analyse the risk factors for retinal...
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| Veröffentlicht in: | Thrombosis research 2024-12, Vol.244, p.109207, Article 109207 |
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| creator | Ortega-Toledo, Paula Rodríguez-Gaspar, Melchor Ángel Barrios-Padilla, Irene Chaxiraxi Mantolán-Sarmiento, Cristina de La Paz-Estrello, Alejandro Mario Fernández-Alonso, Paula Pérez-Hernández, Onán Martín-González, Candelaria |
| description | Central retinal vein occlusion (CRVO) is a frequent and clinically relevant vascular pathology. The main risk factors are the same as systemic cardiovascular risk factors, but recently other significant risk factors have been studied. The aim of this study is to analyse the risk factors for retinal venous thrombosis and their relationship with the development of cancer.
710 patients with retinal vascular pathology were included, of whom 527 had suffered retinal venous thrombosis. Patients were followed up in internal medicine outpatient clinics between September 24, 1999, and April 30, 2022. The incidence of cancer during that time was collected.
Of 527 patients evaluated, 448 (86.7 %) presented cardiovascular risk factors, and 89 (17.2 %) developed some neoplasm, being the most frequent: prostate (19.1 %), colon (16.9 %), skin (12.4 %), breast (9.0 %). Retinal venous thrombosis was related to the development of neoplasms during follow-up time (Log Rank = 5.28, p = 0.022; Breslow = 4.84, p = 0.028). Other significant factors were age above the median, smoking, HbA1c levels, and homocysteine levels higher than the median, and cholesterol and LDL-Cholesterol lower than the median. Age above the median (p |
| doi_str_mv | 10.1016/j.thromres.2024.109207 |
| format | Article |
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710 patients with retinal vascular pathology were included, of whom 527 had suffered retinal venous thrombosis. Patients were followed up in internal medicine outpatient clinics between September 24, 1999, and April 30, 2022. The incidence of cancer during that time was collected.
Of 527 patients evaluated, 448 (86.7 %) presented cardiovascular risk factors, and 89 (17.2 %) developed some neoplasm, being the most frequent: prostate (19.1 %), colon (16.9 %), skin (12.4 %), breast (9.0 %). Retinal venous thrombosis was related to the development of neoplasms during follow-up time (Log Rank = 5.28, p = 0.022; Breslow = 4.84, p = 0.028). Other significant factors were age above the median, smoking, HbA1c levels, and homocysteine levels higher than the median, and cholesterol and LDL-Cholesterol lower than the median. Age above the median (p < 0.001), smoking (p = 0.003) and levels of cholesterol below the median (p = 0.026) were independently related to the development of neoplasms.
Retinal venous thrombosis is associated with the development of cancer. Other factors related to its development have been identified. If this is confirmed, the implications for the diagnosis, control, and treatment of these patients should be evaluated.
•Central retinal venous thrombosis is a frequent and clinically relevant vascular pathology.•Retinal venous thrombosis was related to the development of neoplasms.•Age, tobacco and low colesterol levels were independently related to the development of neoplasms.</description><identifier>ISSN: 0049-3848</identifier><identifier>ISSN: 1879-2472</identifier><identifier>EISSN: 1879-2472</identifier><identifier>DOI: 10.1016/j.thromres.2024.109207</identifier><identifier>PMID: 39531890</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Adult ; Aged ; cancer-associated thrombosis ; Central retinal vein occlusion ; Female ; Humans ; Male ; Middle Aged ; Neoplasms - blood ; Neoplasms - complications ; Neoplasms - epidemiology ; Retinal vascular disease ; Retinal Vein Occlusion - epidemiology ; Retinal Vein Occlusion - etiology ; Risk Factors ; Vascular risk factors</subject><ispartof>Thrombosis research, 2024-12, Vol.244, p.109207, Article 109207</ispartof><rights>2024 The Authors</rights><rights>Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c245t-60433ef8572ebe2aaad904faa9003dfabcfd59ef5f05dad0ce74b50b188450983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0049384824003396$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39531890$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ortega-Toledo, Paula</creatorcontrib><creatorcontrib>Rodríguez-Gaspar, Melchor Ángel</creatorcontrib><creatorcontrib>Barrios-Padilla, Irene Chaxiraxi</creatorcontrib><creatorcontrib>Mantolán-Sarmiento, Cristina</creatorcontrib><creatorcontrib>de La Paz-Estrello, Alejandro Mario</creatorcontrib><creatorcontrib>Fernández-Alonso, Paula</creatorcontrib><creatorcontrib>Pérez-Hernández, Onán</creatorcontrib><creatorcontrib>Martín-González, Candelaria</creatorcontrib><title>Retinal vascular events and relationship to CANCER development</title><title>Thrombosis research</title><addtitle>Thromb Res</addtitle><description>Central retinal vein occlusion (CRVO) is a frequent and clinically relevant vascular pathology. The main risk factors are the same as systemic cardiovascular risk factors, but recently other significant risk factors have been studied. The aim of this study is to analyse the risk factors for retinal venous thrombosis and their relationship with the development of cancer.
710 patients with retinal vascular pathology were included, of whom 527 had suffered retinal venous thrombosis. Patients were followed up in internal medicine outpatient clinics between September 24, 1999, and April 30, 2022. The incidence of cancer during that time was collected.
Of 527 patients evaluated, 448 (86.7 %) presented cardiovascular risk factors, and 89 (17.2 %) developed some neoplasm, being the most frequent: prostate (19.1 %), colon (16.9 %), skin (12.4 %), breast (9.0 %). Retinal venous thrombosis was related to the development of neoplasms during follow-up time (Log Rank = 5.28, p = 0.022; Breslow = 4.84, p = 0.028). Other significant factors were age above the median, smoking, HbA1c levels, and homocysteine levels higher than the median, and cholesterol and LDL-Cholesterol lower than the median. Age above the median (p < 0.001), smoking (p = 0.003) and levels of cholesterol below the median (p = 0.026) were independently related to the development of neoplasms.
Retinal venous thrombosis is associated with the development of cancer. Other factors related to its development have been identified. If this is confirmed, the implications for the diagnosis, control, and treatment of these patients should be evaluated.
•Central retinal venous thrombosis is a frequent and clinically relevant vascular pathology.•Retinal venous thrombosis was related to the development of neoplasms.•Age, tobacco and low colesterol levels were independently related to the development of neoplasms.</description><subject>Adult</subject><subject>Aged</subject><subject>cancer-associated thrombosis</subject><subject>Central retinal vein occlusion</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasms - blood</subject><subject>Neoplasms - complications</subject><subject>Neoplasms - epidemiology</subject><subject>Retinal vascular disease</subject><subject>Retinal Vein Occlusion - epidemiology</subject><subject>Retinal Vein Occlusion - etiology</subject><subject>Risk Factors</subject><subject>Vascular risk factors</subject><issn>0049-3848</issn><issn>1879-2472</issn><issn>1879-2472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1LAzEQhoMotlb_Qtmjl62TbNJNLmIp9QOKQtFzyCazNGU_arIt-O_d0tarp4HheedlHkLGFCYU6PRhM-nWoa0DxgkDxvulYpBfkCGVuUoZz9klGQJwlWaSywG5iXEDQHOqxDUZZEpkVCoYkscVdr4xVbI30e4qExLcY9PFxDQuCViZzrdNXPtt0rXJfPY-X6wS1yNVu6177pZclaaKeHeaI_L1vPicv6bLj5e3-WyZWsZFl06BZxmWUuQMC2TGGKeAl8YogMyVprClEwpLUYJwxoHFnBcCCiolF6BkNiL3x7vb0H7vMHa69tFiVZkG213UGWUyn1IqaI9Oj6gNbYwBS70NvjbhR1PQB3d6o8_u9MGdPrrrg-NTx66o0f3FzrJ64OkIYP_p3mPQ0XpsLDof0Hbatf6_jl_wCIPY</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Ortega-Toledo, Paula</creator><creator>Rodríguez-Gaspar, Melchor Ángel</creator><creator>Barrios-Padilla, Irene Chaxiraxi</creator><creator>Mantolán-Sarmiento, Cristina</creator><creator>de La Paz-Estrello, Alejandro Mario</creator><creator>Fernández-Alonso, Paula</creator><creator>Pérez-Hernández, Onán</creator><creator>Martín-González, Candelaria</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202412</creationdate><title>Retinal vascular events and relationship to CANCER development</title><author>Ortega-Toledo, Paula ; Rodríguez-Gaspar, Melchor Ángel ; Barrios-Padilla, Irene Chaxiraxi ; Mantolán-Sarmiento, Cristina ; de La Paz-Estrello, Alejandro Mario ; Fernández-Alonso, Paula ; Pérez-Hernández, Onán ; Martín-González, Candelaria</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c245t-60433ef8572ebe2aaad904faa9003dfabcfd59ef5f05dad0ce74b50b188450983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>cancer-associated thrombosis</topic><topic>Central retinal vein occlusion</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasms - blood</topic><topic>Neoplasms - complications</topic><topic>Neoplasms - epidemiology</topic><topic>Retinal vascular disease</topic><topic>Retinal Vein Occlusion - epidemiology</topic><topic>Retinal Vein Occlusion - etiology</topic><topic>Risk Factors</topic><topic>Vascular risk factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ortega-Toledo, Paula</creatorcontrib><creatorcontrib>Rodríguez-Gaspar, Melchor Ángel</creatorcontrib><creatorcontrib>Barrios-Padilla, Irene Chaxiraxi</creatorcontrib><creatorcontrib>Mantolán-Sarmiento, Cristina</creatorcontrib><creatorcontrib>de La Paz-Estrello, Alejandro Mario</creatorcontrib><creatorcontrib>Fernández-Alonso, Paula</creatorcontrib><creatorcontrib>Pérez-Hernández, Onán</creatorcontrib><creatorcontrib>Martín-González, Candelaria</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Thrombosis research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ortega-Toledo, Paula</au><au>Rodríguez-Gaspar, Melchor Ángel</au><au>Barrios-Padilla, Irene Chaxiraxi</au><au>Mantolán-Sarmiento, Cristina</au><au>de La Paz-Estrello, Alejandro Mario</au><au>Fernández-Alonso, Paula</au><au>Pérez-Hernández, Onán</au><au>Martín-González, Candelaria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retinal vascular events and relationship to CANCER development</atitle><jtitle>Thrombosis research</jtitle><addtitle>Thromb Res</addtitle><date>2024-12</date><risdate>2024</risdate><volume>244</volume><spage>109207</spage><pages>109207-</pages><artnum>109207</artnum><issn>0049-3848</issn><issn>1879-2472</issn><eissn>1879-2472</eissn><abstract>Central retinal vein occlusion (CRVO) is a frequent and clinically relevant vascular pathology. The main risk factors are the same as systemic cardiovascular risk factors, but recently other significant risk factors have been studied. The aim of this study is to analyse the risk factors for retinal venous thrombosis and their relationship with the development of cancer.
710 patients with retinal vascular pathology were included, of whom 527 had suffered retinal venous thrombosis. Patients were followed up in internal medicine outpatient clinics between September 24, 1999, and April 30, 2022. The incidence of cancer during that time was collected.
Of 527 patients evaluated, 448 (86.7 %) presented cardiovascular risk factors, and 89 (17.2 %) developed some neoplasm, being the most frequent: prostate (19.1 %), colon (16.9 %), skin (12.4 %), breast (9.0 %). Retinal venous thrombosis was related to the development of neoplasms during follow-up time (Log Rank = 5.28, p = 0.022; Breslow = 4.84, p = 0.028). Other significant factors were age above the median, smoking, HbA1c levels, and homocysteine levels higher than the median, and cholesterol and LDL-Cholesterol lower than the median. Age above the median (p < 0.001), smoking (p = 0.003) and levels of cholesterol below the median (p = 0.026) were independently related to the development of neoplasms.
Retinal venous thrombosis is associated with the development of cancer. Other factors related to its development have been identified. If this is confirmed, the implications for the diagnosis, control, and treatment of these patients should be evaluated.
•Central retinal venous thrombosis is a frequent and clinically relevant vascular pathology.•Retinal venous thrombosis was related to the development of neoplasms.•Age, tobacco and low colesterol levels were independently related to the development of neoplasms.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>39531890</pmid><doi>10.1016/j.thromres.2024.109207</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged cancer-associated thrombosis Central retinal vein occlusion Female Humans Male Middle Aged Neoplasms - blood Neoplasms - complications Neoplasms - epidemiology Retinal vascular disease Retinal Vein Occlusion - epidemiology Retinal Vein Occlusion - etiology Risk Factors Vascular risk factors |
| title | Retinal vascular events and relationship to CANCER development |
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