Successful generation of fully human, second generation, anti-CD19 CAR T cells for clinical use in patients with diverse autoimmune disorders

B-cell targeting chimeric antigen receptor (CAR) T-cell therapies, which lead to profound B-cell depletion, have been well-established in hematology-oncology. This deep B-cell depletion mechanism has prompted the exploration of their use in B-cell driven autoimmune diseases. We herein report on the...

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Veröffentlicht in:	Cytotherapy (Oxford, England) England), 2025-02, Vol.27 (2), p.236-246
Hauptverfasser:	Mougiakakos, Dimitrios, Sengupta, Ranjita, Gold, Ralf, Schroers, Roland, Haghikia, Aiden, Lorente, Mario, Pendleton, Michael, Register, Ames, Heesen, Christoph, Kröger, Nicolaus, Schett, Georg, Mackensen, Andreas, Podoll, Amber, Gutman, Jonathan, Furie, Richard, Bayer, Ruthee, Distler, Jörg H.W., Dietrich, Sascha, Krönke, Gerhard, Bullinger, Lars, Walker, Karen
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged anti-CD19 chimeric antigen receptor Antigens, CD19 - immunology Autoimmune Diseases - immunology Autoimmune Diseases - therapy Female Humans Immunotherapy, Adoptive - methods Male manufacturing Middle Aged neurological autoimmune disease Receptors, Chimeric Antigen - genetics Receptors, Chimeric Antigen - immunology rheumatological autoimmune disease T-Lymphocytes - immunology Young Adult
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