Baseline-dependent enhancement of working memory by memantine in male rats: Involvement of NMDA receptor subunits and CaMKII signaling

N-methyl-d-aspartate (NMDA) receptors, activated by glutamate, play a crucial role in learning and memory. Memantine (MEM), a non-competitive NMDA receptor antagonist, is currently prescribed for the treatment of Alzheimer's disease or dementia, which meanwhile simultaneously promotes a need to...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 2024-12, Vol.245, p.173904, Article 173904
Hauptverfasser:	Chen, Shuo-Fu, Cheng, Wan-Ju, Chao, Chih-Chang, Kuo, Chun-Hsien, Liao, Ruey-Ming
Format:	Artikel
Sprache:	eng
Schlagworte:	Amygdala Animals Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism Cognitive enhancement Dorsal striatum Excitatory Amino Acid Antagonists - administration & dosage Excitatory Amino Acid Antagonists - pharmacology Male Maze Learning - drug effects Memantine - administration & dosage Memantine - pharmacology Memory, Short-Term - drug effects NMDA receptor antagonist Nucleus accumbens Rats Rats, Sprague-Dawley Receptors, N-Methyl-D-Aspartate - metabolism Signal Transduction - drug effects
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