The role of PRMT1 in cellular regulation and disease: Insights into biochemical functions and emerging inhibitors for cancer therapy

•We discussed the biochemical properties, cellular functions, and significant roles of PRMT1 in various diseases.•We reviewed the key regulatory mechanisms of PRMT1 in cancer development and explored its feasibility as a potential therapeutic target.•We summarized the currently developed inhibitors...

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Veröffentlicht in:	European journal of pharmaceutical sciences 2025-01, Vol.204, p.106958, Article 106958
Hauptverfasser:	Ma, Shiyao, Yi, Shanhui, Zou, Hui, Fan, Shasha, Xiao, Yin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Arginine methylation Cancer therapy Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Humans Inhibitors Neoplasms - drug therapy Neoplasms - metabolism PRMT1 Protein-Arginine N-Methyltransferases - antagonists & inhibitors Protein-Arginine N-Methyltransferases - metabolism Repressor Proteins - antagonists & inhibitors Repressor Proteins - metabolism Tumorigenesis
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