Bioorthogonal Chemistry-Guided Inhalable Nanoprodrug to Circumvent Cisplatin Resistance in Orthotopic Nonsmall Cell Lung Cancer

Pulmonary delivery of anticancer therapeutics has shown encouraging performance in treating nonsmall cell lung cancer (NSCLC), which is characterized by high aggressiveness and poor prognosis. Cisplatin, a key member of the family of DNA alkylating agents, is extensively employed during NSCLC therap...

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Veröffentlicht in:	ACS nano 2024-11, Vol.18 (46), p.32103-32117
Hauptverfasser:	Tang, Lu, Yin, Yue, Cao, Yuqi, Liu, Hening, Qing, Guangchao, Fu, Cong, Li, Zixuan, Zhu, Yuanbo, Shu, Weijie, He, Shun, Gao, Jifan, Zhang, Yi, Wang, Zihan, Bu, Jianlan, Li, Xuejing, Zhu, Mengliang, Liang, Xing-Jie, Wang, Wei
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Animals Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor Cell Proliferation - drug effects Cell Survival - drug effects Cisplatin - chemistry Cisplatin - pharmacology Drug Resistance, Neoplasm - drug effects Drug Screening Assays, Antitumor Humans Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Mice Mice, Inbred BALB C Mice, Nude Micelles Nanoparticles - chemistry Nitric Oxide - chemistry Nitric Oxide - metabolism Prodrugs - chemistry Prodrugs - pharmacology
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