Activation of γ-globin expression by a common variant disrupting IKAROS-binding motif in β-thalassemia

Programmed silencing of γ-globin genes in adult erythropoiesis is mediated by several chromatin remodeling complexes, which determine the stage-specific genome architecture in this region. Identification of cis- or trans-acting mutations contributing to the diverse extent of Hb F might illustrate th...

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Veröffentlicht in:	Journal of genetics and genomics 2024-11
Hauptverfasser:	Luo, Hualei, Wang, Jueheng, Qin, Lang, Zhang, Xinhua, Liu, Hailiang, Niu, Chao, Song, Mengyang, Shao, Congwen, Xu, Peng, Yu, Miao, Zhang, Haokun, Ye, Yuhua, Xu, Xiangmin
Format:	Artikel
Sprache:	eng
Schlagworte:	adults chromatin epistasis erythropoiesis Fetal hemoglobin gene editing genomics IKAROS loci Locus control region multigene family Single nucleotide polymorphism β-thalassemia
Online-Zugang:	Volltext
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