Increased angiopoietin-1 improves nailfold capillary morphology in patients with systemic sclerosis
Raynaud's phenomenon is a common symptom of systemic sclerosis. We previously reported that elbow heating increases angiopoietin-1 in the fingertips and alleviates Raynaud's phenomenon. Angiopoietin-1 levels decrease in patients with systemic sclerosis with severe capillary damage. We aime...
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| Veröffentlicht in: | Microvascular research 2025-01, Vol.157, p.104761, Article 104761 |
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| creator | Shima, Yoshihito Watanabe, Akane Inoue, Nobuto Maruyama, Tetsuya Kunitomo, Eiji Matsushima, Yuji Kumanogoh, Atsushi |
| description | Raynaud's phenomenon is a common symptom of systemic sclerosis. We previously reported that elbow heating increases angiopoietin-1 in the fingertips and alleviates Raynaud's phenomenon. Angiopoietin-1 levels decrease in patients with systemic sclerosis with severe capillary damage. We aimed to conduct a prospective study to confirm whether the increase in angiopoietin-1 caused by heating modifies capillary morphology.
The left ring fingers of 19 patients with systemic sclerosis were monitored six times at 4-week intervals using capillaroscopy, during which both elbows were heated using disposable heating pads for 8 weeks. Blood samples were collected from the same fingertips four times—before heating, twice during heating, and once after heating—to measure angiopoietin-1.
In six patients, the peak increase in angiopoietin-1 occurred 4 weeks after the start of heating, whereas in seven patients, the peak value was observed 4 weeks after the termination thereof. No change in the density of the front-row capillaries was observed by capillaroscopy. The proportion of hairpin-shaped capillaries increased from 20.2 % during the preheating period to 26.6 % during the heating period (p = 0.00107). When a correlation coefficient of 0.6 or higher was set as significant, there was a strong correlation between changes in fingertip angiopoietin-1 levels and changes in the proportion of hairpin-shaped capillaries in six patients.
Increased angiopoietin-1 levels in the fingertip due to elbow heating may improve the peripheral capillary morphology in patients with systemic sclerosis.
[Display omitted]
•Raynaud's phenomenon is a common symptom of systemic sclerosis (SSc)•We aimed to confirm if heating modifies capillary morphology•Elbow heating in patients with SSc increased angiopoietin-1 levels•In some cases, heating improved capillary morphology in the nailfold |
| doi_str_mv | 10.1016/j.mvr.2024.104761 |
| format | Article |
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The left ring fingers of 19 patients with systemic sclerosis were monitored six times at 4-week intervals using capillaroscopy, during which both elbows were heated using disposable heating pads for 8 weeks. Blood samples were collected from the same fingertips four times—before heating, twice during heating, and once after heating—to measure angiopoietin-1.
In six patients, the peak increase in angiopoietin-1 occurred 4 weeks after the start of heating, whereas in seven patients, the peak value was observed 4 weeks after the termination thereof. No change in the density of the front-row capillaries was observed by capillaroscopy. The proportion of hairpin-shaped capillaries increased from 20.2 % during the preheating period to 26.6 % during the heating period (p = 0.00107). When a correlation coefficient of 0.6 or higher was set as significant, there was a strong correlation between changes in fingertip angiopoietin-1 levels and changes in the proportion of hairpin-shaped capillaries in six patients.
Increased angiopoietin-1 levels in the fingertip due to elbow heating may improve the peripheral capillary morphology in patients with systemic sclerosis.
[Display omitted]
•Raynaud's phenomenon is a common symptom of systemic sclerosis (SSc)•We aimed to confirm if heating modifies capillary morphology•Elbow heating in patients with SSc increased angiopoietin-1 levels•In some cases, heating improved capillary morphology in the nailfold</description><identifier>ISSN: 0026-2862</identifier><identifier>ISSN: 1095-9319</identifier><identifier>EISSN: 1095-9319</identifier><identifier>DOI: 10.1016/j.mvr.2024.104761</identifier><identifier>PMID: 39515460</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Angiopoietin-1 ; Angiopoietin-1 - blood ; Biomarkers - blood ; Capillaries - metabolism ; Capillaries - pathology ; Capillaries - physiopathology ; Capillaroscopy ; Female ; Heating ; Humans ; Male ; Microscopic Angioscopy ; Middle Aged ; Nails - blood supply ; Prospective Studies ; Raynaud Disease - blood ; Raynaud Disease - pathology ; Raynaud Disease - physiopathology ; Raynaud's phenomenon ; Scleroderma, Systemic - blood ; Scleroderma, Systemic - physiopathology ; Systemic sclerosis ; Time Factors ; Treatment Outcome ; Up-Regulation</subject><ispartof>Microvascular research, 2025-01, Vol.157, p.104761, Article 104761</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c235t-ce77be10dcbbc0b84f8f8a78362cc5abf8e3a8786b758959aec564cec94687c73</cites><orcidid>0000-0001-8451-9501 ; 0000-0003-4749-7117 ; 0000-0002-2523-2938</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.mvr.2024.104761$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39515460$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shima, Yoshihito</creatorcontrib><creatorcontrib>Watanabe, Akane</creatorcontrib><creatorcontrib>Inoue, Nobuto</creatorcontrib><creatorcontrib>Maruyama, Tetsuya</creatorcontrib><creatorcontrib>Kunitomo, Eiji</creatorcontrib><creatorcontrib>Matsushima, Yuji</creatorcontrib><creatorcontrib>Kumanogoh, Atsushi</creatorcontrib><title>Increased angiopoietin-1 improves nailfold capillary morphology in patients with systemic sclerosis</title><title>Microvascular research</title><addtitle>Microvasc Res</addtitle><description>Raynaud's phenomenon is a common symptom of systemic sclerosis. We previously reported that elbow heating increases angiopoietin-1 in the fingertips and alleviates Raynaud's phenomenon. Angiopoietin-1 levels decrease in patients with systemic sclerosis with severe capillary damage. We aimed to conduct a prospective study to confirm whether the increase in angiopoietin-1 caused by heating modifies capillary morphology.
The left ring fingers of 19 patients with systemic sclerosis were monitored six times at 4-week intervals using capillaroscopy, during which both elbows were heated using disposable heating pads for 8 weeks. Blood samples were collected from the same fingertips four times—before heating, twice during heating, and once after heating—to measure angiopoietin-1.
In six patients, the peak increase in angiopoietin-1 occurred 4 weeks after the start of heating, whereas in seven patients, the peak value was observed 4 weeks after the termination thereof. No change in the density of the front-row capillaries was observed by capillaroscopy. The proportion of hairpin-shaped capillaries increased from 20.2 % during the preheating period to 26.6 % during the heating period (p = 0.00107). When a correlation coefficient of 0.6 or higher was set as significant, there was a strong correlation between changes in fingertip angiopoietin-1 levels and changes in the proportion of hairpin-shaped capillaries in six patients.
Increased angiopoietin-1 levels in the fingertip due to elbow heating may improve the peripheral capillary morphology in patients with systemic sclerosis.
[Display omitted]
•Raynaud's phenomenon is a common symptom of systemic sclerosis (SSc)•We aimed to confirm if heating modifies capillary morphology•Elbow heating in patients with SSc increased angiopoietin-1 levels•In some cases, heating improved capillary morphology in the nailfold</description><subject>Adult</subject><subject>Aged</subject><subject>Angiopoietin-1</subject><subject>Angiopoietin-1 - blood</subject><subject>Biomarkers - blood</subject><subject>Capillaries - metabolism</subject><subject>Capillaries - pathology</subject><subject>Capillaries - physiopathology</subject><subject>Capillaroscopy</subject><subject>Female</subject><subject>Heating</subject><subject>Humans</subject><subject>Male</subject><subject>Microscopic Angioscopy</subject><subject>Middle Aged</subject><subject>Nails - blood supply</subject><subject>Prospective Studies</subject><subject>Raynaud Disease - blood</subject><subject>Raynaud Disease - pathology</subject><subject>Raynaud Disease - physiopathology</subject><subject>Raynaud's phenomenon</subject><subject>Scleroderma, Systemic - blood</subject><subject>Scleroderma, Systemic - physiopathology</subject><subject>Systemic sclerosis</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Up-Regulation</subject><issn>0026-2862</issn><issn>1095-9319</issn><issn>1095-9319</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtP5DAQhC0EguHxA7isfOSSwXbiR8RphXYBCYkLnC2n05nxKImzdmZW8-8xGuDIqdVSVanqI-SasyVnXN1ulsMuLgUTVf4rrfgRWXBWy6IueX1MFowJVQijxBk5T2nDGOeyFqfkrKwll5ViCwJPI0R0CVvqxpUPU_A4-7Hg1A9TDDtMdHS-70LfUnCT73sX93QIcVqHPqz21I90crPHcU70v5_XNO3TjIMHmqDHGJJPl-Skc33Cq897Qd7-_nm9fyyeXx6e7n8_FyBKOReAWjfIWQtNA6wxVWc647QplQCQrukMls5ooxotTS1rhyBVBQh1pYwGXV6Qm0NuLv5vi2m2g0-AufKIYZtsyYXRVR7OspQfpJAbpoidnaIf8jTLmf1gazc2s7UfbO2Bbfb8-ozfNgO2344vmFlwdxBgHrnzGG2CDAaw9RFhtm3wP8S_AxWvjKE</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>Shima, Yoshihito</creator><creator>Watanabe, Akane</creator><creator>Inoue, Nobuto</creator><creator>Maruyama, Tetsuya</creator><creator>Kunitomo, Eiji</creator><creator>Matsushima, Yuji</creator><creator>Kumanogoh, Atsushi</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-8451-9501</orcidid><orcidid>https://orcid.org/0000-0003-4749-7117</orcidid><orcidid>https://orcid.org/0000-0002-2523-2938</orcidid></search><sort><creationdate>202501</creationdate><title>Increased angiopoietin-1 improves nailfold capillary morphology in patients with systemic sclerosis</title><author>Shima, Yoshihito ; Watanabe, Akane ; Inoue, Nobuto ; Maruyama, Tetsuya ; Kunitomo, Eiji ; Matsushima, Yuji ; Kumanogoh, Atsushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c235t-ce77be10dcbbc0b84f8f8a78362cc5abf8e3a8786b758959aec564cec94687c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Angiopoietin-1</topic><topic>Angiopoietin-1 - blood</topic><topic>Biomarkers - blood</topic><topic>Capillaries - metabolism</topic><topic>Capillaries - pathology</topic><topic>Capillaries - physiopathology</topic><topic>Capillaroscopy</topic><topic>Female</topic><topic>Heating</topic><topic>Humans</topic><topic>Male</topic><topic>Microscopic Angioscopy</topic><topic>Middle Aged</topic><topic>Nails - blood supply</topic><topic>Prospective Studies</topic><topic>Raynaud Disease - blood</topic><topic>Raynaud Disease - pathology</topic><topic>Raynaud Disease - physiopathology</topic><topic>Raynaud's phenomenon</topic><topic>Scleroderma, Systemic - blood</topic><topic>Scleroderma, Systemic - physiopathology</topic><topic>Systemic sclerosis</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Up-Regulation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shima, Yoshihito</creatorcontrib><creatorcontrib>Watanabe, Akane</creatorcontrib><creatorcontrib>Inoue, Nobuto</creatorcontrib><creatorcontrib>Maruyama, Tetsuya</creatorcontrib><creatorcontrib>Kunitomo, Eiji</creatorcontrib><creatorcontrib>Matsushima, Yuji</creatorcontrib><creatorcontrib>Kumanogoh, Atsushi</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Microvascular research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shima, Yoshihito</au><au>Watanabe, Akane</au><au>Inoue, Nobuto</au><au>Maruyama, Tetsuya</au><au>Kunitomo, Eiji</au><au>Matsushima, Yuji</au><au>Kumanogoh, Atsushi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased angiopoietin-1 improves nailfold capillary morphology in patients with systemic sclerosis</atitle><jtitle>Microvascular research</jtitle><addtitle>Microvasc Res</addtitle><date>2025-01</date><risdate>2025</risdate><volume>157</volume><spage>104761</spage><pages>104761-</pages><artnum>104761</artnum><issn>0026-2862</issn><issn>1095-9319</issn><eissn>1095-9319</eissn><abstract>Raynaud's phenomenon is a common symptom of systemic sclerosis. We previously reported that elbow heating increases angiopoietin-1 in the fingertips and alleviates Raynaud's phenomenon. Angiopoietin-1 levels decrease in patients with systemic sclerosis with severe capillary damage. We aimed to conduct a prospective study to confirm whether the increase in angiopoietin-1 caused by heating modifies capillary morphology.
The left ring fingers of 19 patients with systemic sclerosis were monitored six times at 4-week intervals using capillaroscopy, during which both elbows were heated using disposable heating pads for 8 weeks. Blood samples were collected from the same fingertips four times—before heating, twice during heating, and once after heating—to measure angiopoietin-1.
In six patients, the peak increase in angiopoietin-1 occurred 4 weeks after the start of heating, whereas in seven patients, the peak value was observed 4 weeks after the termination thereof. No change in the density of the front-row capillaries was observed by capillaroscopy. The proportion of hairpin-shaped capillaries increased from 20.2 % during the preheating period to 26.6 % during the heating period (p = 0.00107). When a correlation coefficient of 0.6 or higher was set as significant, there was a strong correlation between changes in fingertip angiopoietin-1 levels and changes in the proportion of hairpin-shaped capillaries in six patients.
Increased angiopoietin-1 levels in the fingertip due to elbow heating may improve the peripheral capillary morphology in patients with systemic sclerosis.
[Display omitted]
•Raynaud's phenomenon is a common symptom of systemic sclerosis (SSc)•We aimed to confirm if heating modifies capillary morphology•Elbow heating in patients with SSc increased angiopoietin-1 levels•In some cases, heating improved capillary morphology in the nailfold</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39515460</pmid><doi>10.1016/j.mvr.2024.104761</doi><orcidid>https://orcid.org/0000-0001-8451-9501</orcidid><orcidid>https://orcid.org/0000-0003-4749-7117</orcidid><orcidid>https://orcid.org/0000-0002-2523-2938</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Angiopoietin-1 Angiopoietin-1 - blood Biomarkers - blood Capillaries - metabolism Capillaries - pathology Capillaries - physiopathology Capillaroscopy Female Heating Humans Male Microscopic Angioscopy Middle Aged Nails - blood supply Prospective Studies Raynaud Disease - blood Raynaud Disease - pathology Raynaud Disease - physiopathology Raynaud's phenomenon Scleroderma, Systemic - blood Scleroderma, Systemic - physiopathology Systemic sclerosis Time Factors Treatment Outcome Up-Regulation |
| title | Increased angiopoietin-1 improves nailfold capillary morphology in patients with systemic sclerosis |
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