Overexpression of Pin1 regulated by TOP2A, which subsequently stabilizes Pyk2 to promote bortezomib resistance in multiple myeloma

Multiple myeloma (MM), a hematological malignancy of plasma cells, has remained largely incurable owing to drug resistance and disease relapse, which requires novel therapeutic targets and treatment approaches. Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 (Pin1) acts as an oncoprotein link...

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Veröffentlicht in:	Cancer gene therapy 2024-11
Hauptverfasser:	Zhang, Honghao, Chen, Jianyu, Meng, Yabo, Cen, Qingyan, Wang, Hao, Ding, Xiangyang, Ai, Kexin, Yang, Yulu, Gao, Yang, Qiu, Yingqi, Hu, Yuxing, Li, Meifang, He, Yanjie, Li, Yuhua
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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