Opto-chemogenetic inhibition of L-type CaV1 channels in neurons through a membrane-assisted molecular linkage

Genetically encoded inhibitors of CaV1 channels that operate via C-terminus-mediated inhibition (CMI) have been actively pursued. Here, we advance the design of CMI peptides by proposing a membrane-anchoring tag that is sufficient to link the inhibitory modules to the target channel as well as chemi...

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Veröffentlicht in:	Cell reports methods 2024-11, Vol.4 (11), p.100898, Article 100898
Hauptverfasser:	Geng, Jinli, Yang, Yaxiong, Li, Boying, Yu, Zhen, Qiu, Shuang, Zhang, Wen, Gao, Shixin, Liu, Nan, Liu, Yi, Wang, Bo, Fan, Yubo, Xing, Chengfen, Liu, Xiaodong
Format:	Artikel
Sprache:	eng
Schlagworte:	C-terminus-mediated inhibition L-type voltage-gated calcium channels membrane-anchoring Ras tag opto-chemogenetics rapamycin-mediated heterodimerization
Online-Zugang:	Volltext
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