To BE or to PE: Prime editors provide more choices for epitope-editing-based immunotherapy

Epitope editing is a promising strategy for protecting hematopoietic cells from eradication by immunotherapies. Recently, in Cell Stem Cell, Ji et al. applied both base editing (BE) and prime editing (PE) to alter the epitope of CD123 in hematopoietic stem cells for CAR-T therapy against acute myelo...

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Veröffentlicht in:	Cell stem cell 2024-11, Vol.31 (11), p.1557-1559
Hauptverfasser:	Yin, S.M., Li, D.L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Epitopes - immunology Gene Editing Hematopoietic Stem Cells - immunology Hematopoietic Stem Cells - metabolism Humans Immunotherapy - methods Leukemia, Myeloid, Acute - immunology Leukemia, Myeloid, Acute - therapy
Online-Zugang:	Volltext
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