Dietary regulation of silent synapses in the dorsolateral striatum

•High fat diet upregulates silent synapses in the dorsolateral striatum.•High fat diet induced changes in silent synapses occur over an extended period.•High fat diet induces a loss of stubby spines in the indirect pathway. Obesity and drugs of abuse share overlapping neural circuits and behaviors....

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Veröffentlicht in:Neuroscience 2024-12, Vol.563, p.43-50
Hauptverfasser: Meyers, Allison M., Gnazzo, Federico G., Barrera, Eddy D., Nabatian, Tikva, Chan, Larry, Beeler, Jeff A.
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container_end_page 50
container_issue
container_start_page 43
container_title Neuroscience
container_volume 563
creator Meyers, Allison M.
Gnazzo, Federico G.
Barrera, Eddy D.
Nabatian, Tikva
Chan, Larry
Beeler, Jeff A.
description •High fat diet upregulates silent synapses in the dorsolateral striatum.•High fat diet induced changes in silent synapses occur over an extended period.•High fat diet induces a loss of stubby spines in the indirect pathway. Obesity and drugs of abuse share overlapping neural circuits and behaviors. Silent synapses are transient synapses that are important for remodeling brain circuits. They are prevalent during early development but largely disappear by adulthood. Drugs of abuse increase silent synapses during adulthood and may facilitate reorganizing brain circuits around drug-related experience, facilitating addiction and contributing to relapse during treatment and abstinence. Whether obesity causes alterations in the expression of silent synapses in a manner similar to drugs of abuse has not been examined. Using a dietary-induced obesity paradigm, mice that chronically consumed high fat diet (HFD) exhibited increased silent synapses in both direct and indirect pathway medium spiny neurons in the dorsolateral striatum. Both the time of onset of increased silent synapses and their normalization upon discontinuation of HFD occurs on an extended time scale compared to drugs of abuse. These data demonstrate that chronic consumption of HFD, like drugs of abuse, can alter mechanisms of circuit plasticity likely facilitating neural reorganization analogous to drugs of abuse.
doi_str_mv 10.1016/j.neuroscience.2024.11.005
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source MEDLINE; Access via ScienceDirect (Elsevier)
subjects Addiction
Animals
Corpus Striatum - drug effects
Corpus Striatum - metabolism
Diet, High-Fat - adverse effects
Dorsolateral striatum
High fat diet
Male
Mice
Mice, Inbred C57BL
Neuronal Plasticity - drug effects
Neuronal Plasticity - physiology
Neurons - metabolism
Neurons - physiology
Obesity
Obesity - metabolism
Obesity - physiopathology
Silent synapses
Synapses - physiology
title Dietary regulation of silent synapses in the dorsolateral striatum
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