Optimizing fosfomycin dosing regimens in critically ill patients with and without continuous renal replacement therapy

To define the optimal fosfomycin dosing regimens for drug-resistant gram-negative bacteria in critically ill patients and those receiving continuous renal replacement therapy (CRRT) via Monte Carlo simulations. A pharmacokinetic model for patients with and without CRRT was created to predict fosfomy...

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Veröffentlicht in:	Journal of critical care 2025-02, Vol.85, p.154946, Article 154946
Hauptverfasser:	Charoensareerat, Taniya, Bunrit, Phongphak, Phanpoka, Sasina, Netthanomsak, Thananya, Rungkitwattanakul, Dhakrit, Pattharachayakul, Sutthiporn, Srisawat, Nattachai, Chaijamorn, Weerachai
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Antibiotics Bacteria Bacterial infections Continuous Renal Replacement Therapy Critical Illness Critically ill Dose-Response Relationship, Drug Drug dosages Drug resistance E coli Fosfomycin Fosfomycin - administration & dosage Fosfomycin - pharmacokinetics Fosfomycin - therapeutic use Gram-negative bacteria Gram-Negative Bacterial Infections - drug therapy Gram-Negative Bacterial Infections - microbiology Hemodialysis Humans Infections Kidneys Klebsiella pneumoniae - drug effects Microbial Sensitivity Tests Monte Carlo Method Monte Carlo simulation Pathogens Pharmacodynamics Pharmacokinetics Pseudomonas aeruginosa - drug effects Renal replacement therapy Sepsis
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