Threats from the Candida parapsilosis complex: the surge of multidrug resistance and a hotbed for new emerging pathogens
SUMMARY is a common agent of candidiasis that has gained increased attention in recent years, culminating with its recent consideration as a high-priority fungal pathogen by the World Health Organization. Reasons for this classification are the recent surge in incidence and the alarmingly growing ra...
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| Veröffentlicht in: | Microbiology and molecular biology reviews 2024-12, Vol.88 (4), p.e0002923 |
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| container_title | Microbiology and molecular biology reviews |
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| creator | Gabaldón, Toni |
| description | SUMMARY
is a common agent of candidiasis that has gained increased attention in recent years, culminating with its recent consideration as a high-priority fungal pathogen by the World Health Organization. Reasons for this classification are the recent surge in incidence and the alarmingly growing rates of drug and multidrug resistance. In addition, several closely related species such as
and
may represent recently emerged opportunistic pathogens originated from environmental niches through interspecies hybridization. Here, I review recent research focused on the potential origin and spread of drug resistance and of emerging species in this complex. I will also discuss open questions regarding the possible implications of human activities in these two epidemiological phenomena. |
| doi_str_mv | 10.1128/mmbr.00029-23 |
| format | Article |
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is a common agent of candidiasis that has gained increased attention in recent years, culminating with its recent consideration as a high-priority fungal pathogen by the World Health Organization. Reasons for this classification are the recent surge in incidence and the alarmingly growing rates of drug and multidrug resistance. In addition, several closely related species such as
and
may represent recently emerged opportunistic pathogens originated from environmental niches through interspecies hybridization. Here, I review recent research focused on the potential origin and spread of drug resistance and of emerging species in this complex. I will also discuss open questions regarding the possible implications of human activities in these two epidemiological phenomena.</description><identifier>ISSN: 1092-2172</identifier><identifier>ISSN: 1098-5557</identifier><identifier>EISSN: 1098-5557</identifier><identifier>DOI: 10.1128/mmbr.00029-23</identifier><identifier>PMID: 39508581</identifier><language>eng</language><publisher>United States: American Society for Microbiology</publisher><subject>Antifungal Agents - pharmacology ; Antifungal Agents - therapeutic use ; Candida - drug effects ; Candida - genetics ; Candida parapsilosis - drug effects ; Candida parapsilosis - genetics ; Candidiasis - drug therapy ; Candidiasis - microbiology ; Communicable Diseases, Emerging - epidemiology ; Communicable Diseases, Emerging - microbiology ; Drug Resistance, Multiple, Fungal ; Humans ; Multidrug resistance ; Mycology ; Review ; Special Series: Fungi's Most Wanted</subject><ispartof>Microbiology and molecular biology reviews, 2024-12, Vol.88 (4), p.e0002923</ispartof><rights>Copyright © 2024 American Society for Microbiology.</rights><rights>Copyright American Society for Microbiology Dec 2024</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-a242t-348bd95d15d7c19f120457f5c0f99758044f524bd8f6f1f3372ee4e4e4476ea73</cites><orcidid>0000-0003-0019-1735</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.asm.org/doi/pdf/10.1128/mmbr.00029-23$$EPDF$$P50$$Gasm2$$H</linktopdf><linktohtml>$$Uhttps://journals.asm.org/doi/full/10.1128/mmbr.00029-23$$EHTML$$P50$$Gasm2$$H</linktohtml><link.rule.ids>314,776,780,3175,27901,27902,52726,52727,52728</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39508581$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Heitman, Joseph</contributor><creatorcontrib>Gabaldón, Toni</creatorcontrib><title>Threats from the Candida parapsilosis complex: the surge of multidrug resistance and a hotbed for new emerging pathogens</title><title>Microbiology and molecular biology reviews</title><addtitle>Microbiol Mol Biol Rev</addtitle><addtitle>Microbiol Mol Biol Rev</addtitle><description>SUMMARY
is a common agent of candidiasis that has gained increased attention in recent years, culminating with its recent consideration as a high-priority fungal pathogen by the World Health Organization. Reasons for this classification are the recent surge in incidence and the alarmingly growing rates of drug and multidrug resistance. In addition, several closely related species such as
and
may represent recently emerged opportunistic pathogens originated from environmental niches through interspecies hybridization. Here, I review recent research focused on the potential origin and spread of drug resistance and of emerging species in this complex. I will also discuss open questions regarding the possible implications of human activities in these two epidemiological phenomena.</description><subject>Antifungal Agents - pharmacology</subject><subject>Antifungal Agents - therapeutic use</subject><subject>Candida - drug effects</subject><subject>Candida - genetics</subject><subject>Candida parapsilosis - drug effects</subject><subject>Candida parapsilosis - genetics</subject><subject>Candidiasis - drug therapy</subject><subject>Candidiasis - microbiology</subject><subject>Communicable Diseases, Emerging - epidemiology</subject><subject>Communicable Diseases, Emerging - microbiology</subject><subject>Drug Resistance, Multiple, Fungal</subject><subject>Humans</subject><subject>Multidrug resistance</subject><subject>Mycology</subject><subject>Review</subject><subject>Special Series: Fungi's Most Wanted</subject><issn>1092-2172</issn><issn>1098-5557</issn><issn>1098-5557</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10c1LHDEYBvBQKvWjPXqVQC8ijM3nJulNFm0FwYs9D5nJm9mRyWSazKD-92Z3bQsFySE5_PLwJg9Cp5RcUsr0txCadEkIYaZi_AM6osToSkqpPu7OrGJUsUN0nPNjUUIa8wkdciOJlpoeoeeHTQI7Z-xTDHjeAF7b0fXO4skmO-V-iLnPuI1hGuD5-07kJXWAo8dhGebepaXDCYqa7dgCLtexxZs4N-CwjwmP8IQhQOr6sSup8yZ2MObP6MDbIcOXt_0E_bq5flj_rO7uf9yur-4qywSbKy5044x0VDrVUuMpK29QXrbEG6OkJkJ4yUTjtF956jlXDEBsl1ArsIqfoPN97pTi7wXyXIc-tzAMdoS45JqXT-RUK70q9Ot_9DEuaSzTFSUMWynFaVHVXrUp5pzA11Pqg00vNSX1tpJ6W0m9q6RmvPiLvbc5sH-J7-GztxGWJoD7G_2nMP4K_TKVWA</recordid><startdate>20241218</startdate><enddate>20241218</enddate><creator>Gabaldón, Toni</creator><general>American Society for Microbiology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0019-1735</orcidid></search><sort><creationdate>20241218</creationdate><title>Threats from the Candida parapsilosis complex: the surge of multidrug resistance and a hotbed for new emerging pathogens</title><author>Gabaldón, Toni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a242t-348bd95d15d7c19f120457f5c0f99758044f524bd8f6f1f3372ee4e4e4476ea73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Antifungal Agents - pharmacology</topic><topic>Antifungal Agents - therapeutic use</topic><topic>Candida - drug effects</topic><topic>Candida - genetics</topic><topic>Candida parapsilosis - drug effects</topic><topic>Candida parapsilosis - genetics</topic><topic>Candidiasis - drug therapy</topic><topic>Candidiasis - microbiology</topic><topic>Communicable Diseases, Emerging - epidemiology</topic><topic>Communicable Diseases, Emerging - microbiology</topic><topic>Drug Resistance, Multiple, Fungal</topic><topic>Humans</topic><topic>Multidrug resistance</topic><topic>Mycology</topic><topic>Review</topic><topic>Special Series: Fungi's Most Wanted</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gabaldón, Toni</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - 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is a common agent of candidiasis that has gained increased attention in recent years, culminating with its recent consideration as a high-priority fungal pathogen by the World Health Organization. Reasons for this classification are the recent surge in incidence and the alarmingly growing rates of drug and multidrug resistance. In addition, several closely related species such as
and
may represent recently emerged opportunistic pathogens originated from environmental niches through interspecies hybridization. Here, I review recent research focused on the potential origin and spread of drug resistance and of emerging species in this complex. I will also discuss open questions regarding the possible implications of human activities in these two epidemiological phenomena.</abstract><cop>United States</cop><pub>American Society for Microbiology</pub><pmid>39508581</pmid><doi>10.1128/mmbr.00029-23</doi><tpages>15</tpages><orcidid>https://orcid.org/0000-0003-0019-1735</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1092-2172 |
| ispartof | Microbiology and molecular biology reviews, 2024-12, Vol.88 (4), p.e0002923 |
| issn | 1092-2172 1098-5557 1098-5557 |
| language | eng |
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| source | American Society for Microbiology; MEDLINE |
| subjects | Antifungal Agents - pharmacology Antifungal Agents - therapeutic use Candida - drug effects Candida - genetics Candida parapsilosis - drug effects Candida parapsilosis - genetics Candidiasis - drug therapy Candidiasis - microbiology Communicable Diseases, Emerging - epidemiology Communicable Diseases, Emerging - microbiology Drug Resistance, Multiple, Fungal Humans Multidrug resistance Mycology Review Special Series: Fungi's Most Wanted |
| title | Threats from the Candida parapsilosis complex: the surge of multidrug resistance and a hotbed for new emerging pathogens |
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