Dehydroepiandrosterone (DHEA), a circulating steroid hormone precursor produced potent vasorelaxation in rat aorta and mesenteric arteries through blockade of L-type voltage-dependent calcium channels

Dehydroepiandrosterone (DHEA) is known for potent cardioprotective properties and diminished DHEA level in plasma is often associated with hypertension and age-related anomalies. However, putative ex-vivo vasorelaxation potential of DHEA in systemic resistance vessels like mesenteric arteries and co...

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Veröffentlicht in:	Microvascular research 2025-01, Vol.157, p.104758, Article 104758
Hauptverfasser:	Mishra, Divya, Yadav, Pankaj, Iqbal, Hina, Parashar, Shweta, Negi, Arvind Singh, Chanda, Debabrata
Format:	Artikel
Sprache:	eng
Schlagworte:	Aniline Compounds - pharmacology Animals Aorta - drug effects Aorta - metabolism Calcium Channel Blockers - pharmacology Calcium Channels, L-Type - drug effects Calcium Channels, L-Type - metabolism Calcium Signaling - drug effects Cells, Cultured Dehydroepiandrosterone - pharmacology DHEA Dose-Response Relationship, Drug L-VDCC Male Mesenteric Arteries - drug effects Mesenteric Arteries - metabolism Mesenteric artery Mesenteric Artery, Superior - drug effects Mesenteric Artery, Superior - metabolism Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - metabolism Myocytes, Smooth Muscle - drug effects Myocytes, Smooth Muscle - metabolism Rats Rats, Sprague-Dawley Rats, Wistar Resistance artery Vasodilation - drug effects Vasodilator Agents - pharmacology Vasorelaxation
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