Effect of lubricants type and particle size on the rheological properties and aerosolization behavior of dry powder inhalers

[Display omitted] A commonly used strategy to improve aerosolization behavior of carrier-based dry powder inhalers (DPIs) is the addition of magnesium stearate as a lubricant, yet it may also negatively affect properties of DPIs. Thus, the aim of this study was to find lubricants that could be used...

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Veröffentlicht in:	International journal of pharmaceutics 2024-12, Vol.667 (Pt A), p.124911, Article 124911
Hauptverfasser:	Li, Jiayi, He, Xianhong, Sun, Ying, Song, Ruxiao, Ren, Xuhong, Zhang, Xin, Guan, Jian, Mao, Shirui
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Aerosols Chemistry, Pharmaceutical - methods Drug Carriers - chemistry Dry powder inhaler (DPI) Dry Powder Inhalers Excipients - chemistry Fatty Acids Fluticasone - administration & dosage Fluticasone - chemistry Fumarates In-vitro lung deposition Leucine - chemistry Lubricant Lubricants - chemistry Particle Size Powder properties Powders - chemistry Rheology Stearates - chemistry Stearic Acids - chemistry
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