Causal relationship between cortical structural changes and onset of anxiety disorder: evidence from Mendelian randomization
Abstract Previous studies have reported a correlation between anxiety disorders and changes in brain structure, yet the specific alterations in brain region volumes remain unclear. This study aimed to infer the causal relationship between anxiety disorders and changes in brain structure volume throu...
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| Veröffentlicht in: | Cerebral cortex (New York, N.Y. 1991) N.Y. 1991), 2024-11, Vol.34 (11) |
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| container_title | Cerebral cortex (New York, N.Y. 1991) |
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| creator | Teng, Fei Wang, Mengqi Lu, Zhangyu Zhang, Chunyu Xiao, Linglong Chen, ZhaoMing Huang, Mengshuang Xie, Linglin Chen, Zheyu Wang, Wei |
| description | Abstract
Previous studies have reported a correlation between anxiety disorders and changes in brain structure, yet the specific alterations in brain region volumes remain unclear. This study aimed to infer the causal relationship between anxiety disorders and changes in brain structure volume through Mendelian Randomization analysis. We selected 63 cortical structure volumes from the GWAS database as exposure data and anxiety disorder data from the FinnGen and UK Biobank databases as outcomes. We found a significant correlation between atrophy in the Left precentral volume area (Odds Ratio [OR] = 0.935, 95% Confidence intervals [CI]: 0.891–0.981, P value, P = 0.007) and an increased risk of anxiety disorders. Additionally, changes identified in specific brain regions, such as atrophy in the Right rostral anterior cingulate area (OR = 0.993, 95% CI: 0.987–0.999, P = 0.025) and increased volume in the Left superior parietal area (OR = 1.001, 95% CI: 1.000–1.001, P = 0.028), may correlate with an increased risk of anxiety disorders. Furthermore, both phenotypes demonstrated directional consistency in their respective and overall meta-analyzed OR values pre- and post-merger, enhancing the reliability of the results. This study elucidates the causal relationship between anxiety disorders and specific brain structures, providing new insights for further research into psychiatric disorders. |
| doi_str_mv | 10.1093/cercor/bhae440 |
| format | Article |
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Previous studies have reported a correlation between anxiety disorders and changes in brain structure, yet the specific alterations in brain region volumes remain unclear. This study aimed to infer the causal relationship between anxiety disorders and changes in brain structure volume through Mendelian Randomization analysis. We selected 63 cortical structure volumes from the GWAS database as exposure data and anxiety disorder data from the FinnGen and UK Biobank databases as outcomes. We found a significant correlation between atrophy in the Left precentral volume area (Odds Ratio [OR] = 0.935, 95% Confidence intervals [CI]: 0.891–0.981, P value, P = 0.007) and an increased risk of anxiety disorders. Additionally, changes identified in specific brain regions, such as atrophy in the Right rostral anterior cingulate area (OR = 0.993, 95% CI: 0.987–0.999, P = 0.025) and increased volume in the Left superior parietal area (OR = 1.001, 95% CI: 1.000–1.001, P = 0.028), may correlate with an increased risk of anxiety disorders. Furthermore, both phenotypes demonstrated directional consistency in their respective and overall meta-analyzed OR values pre- and post-merger, enhancing the reliability of the results. This study elucidates the causal relationship between anxiety disorders and specific brain structures, providing new insights for further research into psychiatric disorders.</description><identifier>ISSN: 1047-3211</identifier><identifier>ISSN: 1460-2199</identifier><identifier>EISSN: 1460-2199</identifier><identifier>DOI: 10.1093/cercor/bhae440</identifier><identifier>PMID: 39503246</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Anxiety Disorders - genetics ; Anxiety Disorders - pathology ; Atrophy - pathology ; Cerebral Cortex - diagnostic imaging ; Cerebral Cortex - pathology ; Female ; Genome-Wide Association Study ; Humans ; Magnetic Resonance Imaging ; Male ; Mendelian Randomization Analysis ; Polymorphism, Single Nucleotide</subject><ispartof>Cerebral cortex (New York, N.Y. 1991), 2024-11, Vol.34 (11)</ispartof><rights>The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com 2024</rights><rights>The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c214t-3e6302240fda21d639c66c952088566b11011d3a3fdabe0a8ef21d3e9eb06d73</cites><orcidid>0000-0003-4059-4774</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,1585,27926,27927</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39503246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Teng, Fei</creatorcontrib><creatorcontrib>Wang, Mengqi</creatorcontrib><creatorcontrib>Lu, Zhangyu</creatorcontrib><creatorcontrib>Zhang, Chunyu</creatorcontrib><creatorcontrib>Xiao, Linglong</creatorcontrib><creatorcontrib>Chen, ZhaoMing</creatorcontrib><creatorcontrib>Huang, Mengshuang</creatorcontrib><creatorcontrib>Xie, Linglin</creatorcontrib><creatorcontrib>Chen, Zheyu</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><title>Causal relationship between cortical structural changes and onset of anxiety disorder: evidence from Mendelian randomization</title><title>Cerebral cortex (New York, N.Y. 1991)</title><addtitle>Cereb Cortex</addtitle><description>Abstract
Previous studies have reported a correlation between anxiety disorders and changes in brain structure, yet the specific alterations in brain region volumes remain unclear. This study aimed to infer the causal relationship between anxiety disorders and changes in brain structure volume through Mendelian Randomization analysis. We selected 63 cortical structure volumes from the GWAS database as exposure data and anxiety disorder data from the FinnGen and UK Biobank databases as outcomes. We found a significant correlation between atrophy in the Left precentral volume area (Odds Ratio [OR] = 0.935, 95% Confidence intervals [CI]: 0.891–0.981, P value, P = 0.007) and an increased risk of anxiety disorders. Additionally, changes identified in specific brain regions, such as atrophy in the Right rostral anterior cingulate area (OR = 0.993, 95% CI: 0.987–0.999, P = 0.025) and increased volume in the Left superior parietal area (OR = 1.001, 95% CI: 1.000–1.001, P = 0.028), may correlate with an increased risk of anxiety disorders. Furthermore, both phenotypes demonstrated directional consistency in their respective and overall meta-analyzed OR values pre- and post-merger, enhancing the reliability of the results. This study elucidates the causal relationship between anxiety disorders and specific brain structures, providing new insights for further research into psychiatric disorders.</description><subject>Anxiety Disorders - genetics</subject><subject>Anxiety Disorders - pathology</subject><subject>Atrophy - pathology</subject><subject>Cerebral Cortex - diagnostic imaging</subject><subject>Cerebral Cortex - pathology</subject><subject>Female</subject><subject>Genome-Wide Association Study</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Mendelian Randomization Analysis</subject><subject>Polymorphism, Single Nucleotide</subject><issn>1047-3211</issn><issn>1460-2199</issn><issn>1460-2199</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkD1PwzAQhi0EoqWwMiKPMKT1R-I0bKjiSypi6R459oUaJXGwHaCIH4-hhZXp7nTPvSc9CJ1SMqWk4DMFTlk3q9YS0pTsoTFNBUkYLYr92JM0TzijdISOvH8mhOYsY4doxIuMcJaKMfpcyMHLBjtoZDC282vT4wrCG0CHY3IwKm59cIMKg4utWsvuCTyWncYRh4BtHYd3A2GDtfHWaXCXGF6Nhk4Brp1t8QN0GhojO-zinW3Nx8-zY3RQy8bDya5O0OrmerW4S5aPt_eLq2WiGE1DwkFwwlhKai0Z1YIXSghVZIzM55kQFaWEUs0lj_sKiJxDHTEOBVRE6JxP0Pk2tnf2ZQAfytZ4BU0jO7CDLzmNKgqaz0VEp1tUOeu9g7rsnWml25SUlN_Cy63wcic8HpztsoeqBf2H_xqOwMUWsEP_X9gXylSPWA</recordid><startdate>20241105</startdate><enddate>20241105</enddate><creator>Teng, Fei</creator><creator>Wang, Mengqi</creator><creator>Lu, Zhangyu</creator><creator>Zhang, Chunyu</creator><creator>Xiao, Linglong</creator><creator>Chen, ZhaoMing</creator><creator>Huang, Mengshuang</creator><creator>Xie, Linglin</creator><creator>Chen, Zheyu</creator><creator>Wang, Wei</creator><general>Oxford University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-4059-4774</orcidid></search><sort><creationdate>20241105</creationdate><title>Causal relationship between cortical structural changes and onset of anxiety disorder: evidence from Mendelian randomization</title><author>Teng, Fei ; Wang, Mengqi ; Lu, Zhangyu ; Zhang, Chunyu ; Xiao, Linglong ; Chen, ZhaoMing ; Huang, Mengshuang ; Xie, Linglin ; Chen, Zheyu ; Wang, Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c214t-3e6302240fda21d639c66c952088566b11011d3a3fdabe0a8ef21d3e9eb06d73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Anxiety Disorders - genetics</topic><topic>Anxiety Disorders - pathology</topic><topic>Atrophy - pathology</topic><topic>Cerebral Cortex - diagnostic imaging</topic><topic>Cerebral Cortex - pathology</topic><topic>Female</topic><topic>Genome-Wide Association Study</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Mendelian Randomization Analysis</topic><topic>Polymorphism, Single Nucleotide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Teng, Fei</creatorcontrib><creatorcontrib>Wang, Mengqi</creatorcontrib><creatorcontrib>Lu, Zhangyu</creatorcontrib><creatorcontrib>Zhang, Chunyu</creatorcontrib><creatorcontrib>Xiao, Linglong</creatorcontrib><creatorcontrib>Chen, ZhaoMing</creatorcontrib><creatorcontrib>Huang, Mengshuang</creatorcontrib><creatorcontrib>Xie, Linglin</creatorcontrib><creatorcontrib>Chen, Zheyu</creatorcontrib><creatorcontrib>Wang, Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Teng, Fei</au><au>Wang, Mengqi</au><au>Lu, Zhangyu</au><au>Zhang, Chunyu</au><au>Xiao, Linglong</au><au>Chen, ZhaoMing</au><au>Huang, Mengshuang</au><au>Xie, Linglin</au><au>Chen, Zheyu</au><au>Wang, Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Causal relationship between cortical structural changes and onset of anxiety disorder: evidence from Mendelian randomization</atitle><jtitle>Cerebral cortex (New York, N.Y. 1991)</jtitle><addtitle>Cereb Cortex</addtitle><date>2024-11-05</date><risdate>2024</risdate><volume>34</volume><issue>11</issue><issn>1047-3211</issn><issn>1460-2199</issn><eissn>1460-2199</eissn><abstract>Abstract
Previous studies have reported a correlation between anxiety disorders and changes in brain structure, yet the specific alterations in brain region volumes remain unclear. This study aimed to infer the causal relationship between anxiety disorders and changes in brain structure volume through Mendelian Randomization analysis. We selected 63 cortical structure volumes from the GWAS database as exposure data and anxiety disorder data from the FinnGen and UK Biobank databases as outcomes. We found a significant correlation between atrophy in the Left precentral volume area (Odds Ratio [OR] = 0.935, 95% Confidence intervals [CI]: 0.891–0.981, P value, P = 0.007) and an increased risk of anxiety disorders. Additionally, changes identified in specific brain regions, such as atrophy in the Right rostral anterior cingulate area (OR = 0.993, 95% CI: 0.987–0.999, P = 0.025) and increased volume in the Left superior parietal area (OR = 1.001, 95% CI: 1.000–1.001, P = 0.028), may correlate with an increased risk of anxiety disorders. Furthermore, both phenotypes demonstrated directional consistency in their respective and overall meta-analyzed OR values pre- and post-merger, enhancing the reliability of the results. This study elucidates the causal relationship between anxiety disorders and specific brain structures, providing new insights for further research into psychiatric disorders.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>39503246</pmid><doi>10.1093/cercor/bhae440</doi><orcidid>https://orcid.org/0000-0003-4059-4774</orcidid></addata></record> |
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| subjects | Anxiety Disorders - genetics Anxiety Disorders - pathology Atrophy - pathology Cerebral Cortex - diagnostic imaging Cerebral Cortex - pathology Female Genome-Wide Association Study Humans Magnetic Resonance Imaging Male Mendelian Randomization Analysis Polymorphism, Single Nucleotide |
| title | Causal relationship between cortical structural changes and onset of anxiety disorder: evidence from Mendelian randomization |
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