Exploring the mechanism of ursolic acid in preventing liver fibrosis and improving intestinal microbiota based on NOX2/NLRP3 inflammasome signaling pathway

Early-stage liver fibrosis can be reversed; however, the underlying mechanisms remain incompletely understood. The intestinal tract hosts a substantial and diverse microbiota involved in various physiological activities and is closely linked to chronic liver disease. Previous studies have indicated...

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Veröffentlicht in:	Chemico-biological interactions 2025-01, Vol.405, p.111305, Article 111305
Hauptverfasser:	Liu, Qi, Liu, Lin-Xiang, Li, Bi-Min, Zhang, Wang, Zhang, Yue, Chen, Peng, Huang, Chen-Kai, Nie, Yuan, Zhu, Xuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carbon Tetrachloride Gastrointestinal Microbiome - drug effects Inflammasomes - metabolism Intestinal microbiota Liver - drug effects Liver - metabolism Liver - pathology Liver Cirrhosis - drug therapy Liver Cirrhosis - metabolism Liver Cirrhosis - pathology Liver Cirrhosis - prevention & control Liver fibrosis Male Mice Mice, Inbred C57BL Mice, Knockout NADPH oxidase 2 NADPH Oxidase 2 - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 inflammasome Signal Transduction - drug effects Triterpenes - pharmacology Ursolic Acid
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