Tubulin/HDAC dual-target inhibitors: Insights from design strategies, SARs, and therapeutic potential

Microtubules, one of the cytoskeletons in eukaryotic cells, maintain the proper operation of several cellular functions. Additionally, they are regulated by the acetylation of HDAC6 and SIRT2 which affects microtubule dynamics. Given the fact that tubulin and HDAC inhibitors play a synergistic effec...

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Veröffentlicht in:	European journal of medicinal chemistry 2025-01, Vol.281, p.117022, Article 117022
Hauptverfasser:	Zhang, Zhen, Su, Rui, Liu, Junao, Chen, Keyu, Wu, Chengjun, Sun, Pinghua, Sun, Tiemin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticancer Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Drug Design Dual inhibitors HDAC Histone Deacetylase Inhibitors - chemical synthesis Histone Deacetylase Inhibitors - chemistry Histone Deacetylase Inhibitors - pharmacology Histone Deacetylases - metabolism Humans Molecular Structure Neoplasms - drug therapy Structure-Activity Relationship Synergistic effects Tubulin Tubulin - metabolism Tubulin Modulators - chemical synthesis Tubulin Modulators - chemistry Tubulin Modulators - pharmacology Tubulin Modulators - therapeutic use
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