Reversal of Reactivity of Heyns Intermediate for the Concise Synthesis of Substituted 3‑Hydroxyquinolines
An efficient and general method for the synthesis of 3-hydroxyquinolines has been achieved from o-acylanilines and α-hydroxyketones in good yields. The strategy involves the intramolecular reverse trapping of the in situ generated aminoenol intermediate with an electrophilic carbonyl, viz. an interr...
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| Veröffentlicht in: | Journal of organic chemistry 2024-11, Vol.89 (22), p.16899-16908 |
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| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
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