Evaluation of Dermal Wound Healing Potential: Phytochemical Characterization, Anti-inflammatory, Antioxidant, and Antimicrobial Activities of Euphorbia guyoniana Boiss. & Reut. Latex

Evaluation of Dermal Wound Healing Potential: Phytochemical Characterization, Anti-inflammatory, Antioxidant, and Antimicrobial Activities of Euphorbia guyoniana Boiss. & Reut. Latex

This study investigates the wound-healing potential of Euphorbia guyoniana latex (EGL) in male Wistar rats, along with its biochemical composition and biological activities. Phytochemical analysis identified moderate levels of phenolics, flavonoids, and tannins, with HPLC revealing five phenolic com...

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Veröffentlicht in:Chemistry & biodiversity 2024-11, p.e202402284
Hauptverfasser: Segueni, Khaoula, Chouikh, Atef, Laouini, Salah Eddine, Bouafia, Abderrhmane, Tlili, Mohammed Laid, Laib, Ibtissam, Boudebia, Ouafa, Khelef, Yahia Khelef, Abdullah, Mahmood M S, Abdullah, Johar Amin Ahmed, Bin Emran, Talha
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container_title Chemistry & biodiversity
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creator Segueni, Khaoula
Chouikh, Atef
Laouini, Salah Eddine
Bouafia, Abderrhmane
Tlili, Mohammed Laid
Laib, Ibtissam
Boudebia, Ouafa
Khelef, Yahia Khelef
Abdullah, Mahmood M S
Abdullah, Johar Amin Ahmed
Bin Emran, Talha
description This study investigates the wound-healing potential of Euphorbia guyoniana latex (EGL) in male Wistar rats, along with its biochemical composition and biological activities. Phytochemical analysis identified moderate levels of phenolics, flavonoids, and tannins, with HPLC revealing five phenolic compounds. EGL demonstrated strong antioxidant activity in DPPH assays, surpassing ascorbic acid in protecting red blood cells. Its performance in the ß-carotene-linoleic acid assay was robust, though its FRAP assay results were weaker. EGL also exhibited significant anti-inflammatory activity, comparable to Acetylsalicylic acid, and showed antibacterial effects against Listeria innocua. In Vivo, EGL-infused ointments accelerated wound healing, reducing epithelialization periods to 12-16 days, with a higher wound contraction rate compared to controls. The study concludes that EGL, rich in bioactive compounds, holds potential as a promising natural agent for wound healing, owing to its potent antioxidant, anti-inflammatory, and antibacterial properties.
doi_str_mv 10.1002/cbdv.202402284
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title Evaluation of Dermal Wound Healing Potential: Phytochemical Characterization, Anti-inflammatory, Antioxidant, and Antimicrobial Activities of Euphorbia guyoniana Boiss. & Reut. Latex
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