Metabolic biomarkers of appetite control in Parkinson's disease patients with and without cognitive impairment
Appetite dysregulation in Parkinson's Disease (PD) appears to be linked to physical and cognitive deterioration. PD patients with and without cognitive impairment (CI) were compared to an age-matched control group to explore predictors of appetite control in fasting and post-prandial conditions...
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| Veröffentlicht in: | Clinical nutrition ESPEN 2024-12, Vol.64, p.425-434 |
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| creator | Siervo, Mario Johnston, Fionnuala Calton, Emily James, Anthony Stephan, Blossom C.M. Hornsby, Amanda K.E. Davies, Jeffrey S. Burn, David |
| description | Appetite dysregulation in Parkinson's Disease (PD) appears to be linked to physical and cognitive deterioration. PD patients with and without cognitive impairment (CI) were compared to an age-matched control group to explore predictors of appetite control in fasting and post-prandial conditions.
Fifty-five patients were recruited and divided into three groups: twenty controls (age: 74 y, BMI: 25.8 kg/m2), nineteen PD patients without CI (72.5 y, 25.1 kg/m2) and sixteen PD patients with CI (74.3 y, 24.0 kg/m2). Self-reported appetite perception and circulating blood metabolic biomarkers were measured in fasting and over a 3-h post-prandial period. Biomarkers included glucose, insulin, tumour necrosis factor alpha (TNF-α), leptin, acyl-ghrelin, total ghrelin, peptide YY (PYY), glucagon like peptide 1 (GLP-1), insulin growth factor 1 (IGF-1), growth factor (GF) and triglycerides. Patients were then provided with a mixed meal to eat ad libitum with the aim to evaluate links between metabolic biomarkers and control of energy intake.
PD patients with CI had a significant lower protein intake (7.4 ± 2.5 g, p = 0.01) compared to controls (21.9 ± 3.1 g) and PD patients without CI (14.3 ± 3.0 g). Post-prandial plasma GLP-1 concentrations were associated with decreased hunger perception (B±SE, −5.3 ± 2.4 mm·h−1, p = 0.04). PYY concentrations were significantly associated with GLP-1 in fasting (r = 0.40, p = 0.005) and post-prandial (r = 0.46, p |
| doi_str_mv | 10.1016/j.clnesp.2024.10.167 |
| format | Article |
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Fifty-five patients were recruited and divided into three groups: twenty controls (age: 74 y, BMI: 25.8 kg/m2), nineteen PD patients without CI (72.5 y, 25.1 kg/m2) and sixteen PD patients with CI (74.3 y, 24.0 kg/m2). Self-reported appetite perception and circulating blood metabolic biomarkers were measured in fasting and over a 3-h post-prandial period. Biomarkers included glucose, insulin, tumour necrosis factor alpha (TNF-α), leptin, acyl-ghrelin, total ghrelin, peptide YY (PYY), glucagon like peptide 1 (GLP-1), insulin growth factor 1 (IGF-1), growth factor (GF) and triglycerides. Patients were then provided with a mixed meal to eat ad libitum with the aim to evaluate links between metabolic biomarkers and control of energy intake.
PD patients with CI had a significant lower protein intake (7.4 ± 2.5 g, p = 0.01) compared to controls (21.9 ± 3.1 g) and PD patients without CI (14.3 ± 3.0 g). Post-prandial plasma GLP-1 concentrations were associated with decreased hunger perception (B±SE, −5.3 ± 2.4 mm·h−1, p = 0.04). PYY concentrations were significantly associated with GLP-1 in fasting (r = 0.40, p = 0.005) and post-prandial (r = 0.46, p < 0.001) conditions. In a multivariate model, post-prandial PYY concentrations were a significant predictor of ad libitum energy intake in all subjects (B±SE, −87.5 ± 34.9 kcal, p = 0.01) and in patients with PD (B±SE, −106.8 ± 44.9 kcal, p = 0.04).
PYY and GLP-1 appeared to influence appetite control in PD patients and their roles merit further investigation.</description><identifier>ISSN: 2405-4577</identifier><identifier>EISSN: 2405-4577</identifier><identifier>DOI: 10.1016/j.clnesp.2024.10.167</identifier><identifier>PMID: 39491667</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Aged ; Aged, 80 and over ; Appetite ; Appetite Regulation ; Biomarkers ; Biomarkers - blood ; Blood Glucose - metabolism ; Case-Control Studies ; Cognitive Dysfunction - blood ; Cognitive function ; Energy Intake ; Fasting ; Female ; Ghrelin - blood ; GLP-1 ; Glucagon-Like Peptide 1 - blood ; Humans ; Insulin - blood ; Leptin - blood ; Male ; Parkinson disease ; Parkinson Disease - blood ; Peptide YY - blood ; Postprandial Period ; PYY</subject><ispartof>Clinical nutrition ESPEN, 2024-12, Vol.64, p.425-434</ispartof><rights>2024 The Author(s)</rights><rights>Copyright © 2024 The Author(s). Published by Elsevier Ltd.. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c241t-22bbd7fb09dc0617ec3f558c7e1c3c000403532fbcacbd2b15ce30c146813bbc3</cites><orcidid>0000-0001-5515-0944</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39491667$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Siervo, Mario</creatorcontrib><creatorcontrib>Johnston, Fionnuala</creatorcontrib><creatorcontrib>Calton, Emily</creatorcontrib><creatorcontrib>James, Anthony</creatorcontrib><creatorcontrib>Stephan, Blossom C.M.</creatorcontrib><creatorcontrib>Hornsby, Amanda K.E.</creatorcontrib><creatorcontrib>Davies, Jeffrey S.</creatorcontrib><creatorcontrib>Burn, David</creatorcontrib><title>Metabolic biomarkers of appetite control in Parkinson's disease patients with and without cognitive impairment</title><title>Clinical nutrition ESPEN</title><addtitle>Clin Nutr ESPEN</addtitle><description>Appetite dysregulation in Parkinson's Disease (PD) appears to be linked to physical and cognitive deterioration. PD patients with and without cognitive impairment (CI) were compared to an age-matched control group to explore predictors of appetite control in fasting and post-prandial conditions.
Fifty-five patients were recruited and divided into three groups: twenty controls (age: 74 y, BMI: 25.8 kg/m2), nineteen PD patients without CI (72.5 y, 25.1 kg/m2) and sixteen PD patients with CI (74.3 y, 24.0 kg/m2). Self-reported appetite perception and circulating blood metabolic biomarkers were measured in fasting and over a 3-h post-prandial period. Biomarkers included glucose, insulin, tumour necrosis factor alpha (TNF-α), leptin, acyl-ghrelin, total ghrelin, peptide YY (PYY), glucagon like peptide 1 (GLP-1), insulin growth factor 1 (IGF-1), growth factor (GF) and triglycerides. Patients were then provided with a mixed meal to eat ad libitum with the aim to evaluate links between metabolic biomarkers and control of energy intake.
PD patients with CI had a significant lower protein intake (7.4 ± 2.5 g, p = 0.01) compared to controls (21.9 ± 3.1 g) and PD patients without CI (14.3 ± 3.0 g). Post-prandial plasma GLP-1 concentrations were associated with decreased hunger perception (B±SE, −5.3 ± 2.4 mm·h−1, p = 0.04). PYY concentrations were significantly associated with GLP-1 in fasting (r = 0.40, p = 0.005) and post-prandial (r = 0.46, p < 0.001) conditions. In a multivariate model, post-prandial PYY concentrations were a significant predictor of ad libitum energy intake in all subjects (B±SE, −87.5 ± 34.9 kcal, p = 0.01) and in patients with PD (B±SE, −106.8 ± 44.9 kcal, p = 0.04).
PYY and GLP-1 appeared to influence appetite control in PD patients and their roles merit further investigation.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Appetite</subject><subject>Appetite Regulation</subject><subject>Biomarkers</subject><subject>Biomarkers - blood</subject><subject>Blood Glucose - metabolism</subject><subject>Case-Control Studies</subject><subject>Cognitive Dysfunction - blood</subject><subject>Cognitive function</subject><subject>Energy Intake</subject><subject>Fasting</subject><subject>Female</subject><subject>Ghrelin - blood</subject><subject>GLP-1</subject><subject>Glucagon-Like Peptide 1 - blood</subject><subject>Humans</subject><subject>Insulin - blood</subject><subject>Leptin - blood</subject><subject>Male</subject><subject>Parkinson disease</subject><subject>Parkinson Disease - blood</subject><subject>Peptide YY - blood</subject><subject>Postprandial Period</subject><subject>PYY</subject><issn>2405-4577</issn><issn>2405-4577</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1vFDEMhiMEolXpP0AoN7jskq-Z7FyQUFU-pCI4wDlKPB7wMpMMSbaIf0-2WxAnTrHs543lh7GnUmylkP3L_RbmiGXdKqHM9tjt7QN2rozoNqaz9uE_9Rm7LGUvRMsNg5HiMTvTgxlk39tzFj9g9SHNBDxQWnz-jrnwNHG_rlipIocUa04zp8g_tTHFkuLzwkcq6Avy1VfCWAv_SfUb93G8K9KhtuDXSJVukdOyespLw56wR5OfC17evxfsy5vrz1fvNjcf376_en2zAWVk3SgVwminIIYRRC8tgp66bgcWJWhopxihO62mAB7CqILsALUAafqd1CGAvmAvTv-uOf04YKluoQI4zz5iOhSnpdI70Vk5NNScUMiplIyTWzM1Eb-cFO4o2-3dSbY7yr7r9rbFnt1vOIQFx7-hP2ob8OoEYLvzljC7As0U4EgZobox0f83_AZ2RZSu</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Siervo, Mario</creator><creator>Johnston, Fionnuala</creator><creator>Calton, Emily</creator><creator>James, Anthony</creator><creator>Stephan, Blossom C.M.</creator><creator>Hornsby, Amanda K.E.</creator><creator>Davies, Jeffrey S.</creator><creator>Burn, David</creator><general>Elsevier Ltd</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5515-0944</orcidid></search><sort><creationdate>202412</creationdate><title>Metabolic biomarkers of appetite control in Parkinson's disease patients with and without cognitive impairment</title><author>Siervo, Mario ; Johnston, Fionnuala ; Calton, Emily ; James, Anthony ; Stephan, Blossom C.M. ; Hornsby, Amanda K.E. ; Davies, Jeffrey S. ; Burn, David</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c241t-22bbd7fb09dc0617ec3f558c7e1c3c000403532fbcacbd2b15ce30c146813bbc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Appetite</topic><topic>Appetite Regulation</topic><topic>Biomarkers</topic><topic>Biomarkers - blood</topic><topic>Blood Glucose - metabolism</topic><topic>Case-Control Studies</topic><topic>Cognitive Dysfunction - blood</topic><topic>Cognitive function</topic><topic>Energy Intake</topic><topic>Fasting</topic><topic>Female</topic><topic>Ghrelin - blood</topic><topic>GLP-1</topic><topic>Glucagon-Like Peptide 1 - blood</topic><topic>Humans</topic><topic>Insulin - blood</topic><topic>Leptin - blood</topic><topic>Male</topic><topic>Parkinson disease</topic><topic>Parkinson Disease - blood</topic><topic>Peptide YY - blood</topic><topic>Postprandial Period</topic><topic>PYY</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Siervo, Mario</creatorcontrib><creatorcontrib>Johnston, Fionnuala</creatorcontrib><creatorcontrib>Calton, Emily</creatorcontrib><creatorcontrib>James, Anthony</creatorcontrib><creatorcontrib>Stephan, Blossom C.M.</creatorcontrib><creatorcontrib>Hornsby, Amanda K.E.</creatorcontrib><creatorcontrib>Davies, Jeffrey S.</creatorcontrib><creatorcontrib>Burn, David</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical nutrition ESPEN</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Siervo, Mario</au><au>Johnston, Fionnuala</au><au>Calton, Emily</au><au>James, Anthony</au><au>Stephan, Blossom C.M.</au><au>Hornsby, Amanda K.E.</au><au>Davies, Jeffrey S.</au><au>Burn, David</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Metabolic biomarkers of appetite control in Parkinson's disease patients with and without cognitive impairment</atitle><jtitle>Clinical nutrition ESPEN</jtitle><addtitle>Clin Nutr ESPEN</addtitle><date>2024-12</date><risdate>2024</risdate><volume>64</volume><spage>425</spage><epage>434</epage><pages>425-434</pages><issn>2405-4577</issn><eissn>2405-4577</eissn><abstract>Appetite dysregulation in Parkinson's Disease (PD) appears to be linked to physical and cognitive deterioration. PD patients with and without cognitive impairment (CI) were compared to an age-matched control group to explore predictors of appetite control in fasting and post-prandial conditions.
Fifty-five patients were recruited and divided into three groups: twenty controls (age: 74 y, BMI: 25.8 kg/m2), nineteen PD patients without CI (72.5 y, 25.1 kg/m2) and sixteen PD patients with CI (74.3 y, 24.0 kg/m2). Self-reported appetite perception and circulating blood metabolic biomarkers were measured in fasting and over a 3-h post-prandial period. Biomarkers included glucose, insulin, tumour necrosis factor alpha (TNF-α), leptin, acyl-ghrelin, total ghrelin, peptide YY (PYY), glucagon like peptide 1 (GLP-1), insulin growth factor 1 (IGF-1), growth factor (GF) and triglycerides. Patients were then provided with a mixed meal to eat ad libitum with the aim to evaluate links between metabolic biomarkers and control of energy intake.
PD patients with CI had a significant lower protein intake (7.4 ± 2.5 g, p = 0.01) compared to controls (21.9 ± 3.1 g) and PD patients without CI (14.3 ± 3.0 g). Post-prandial plasma GLP-1 concentrations were associated with decreased hunger perception (B±SE, −5.3 ± 2.4 mm·h−1, p = 0.04). PYY concentrations were significantly associated with GLP-1 in fasting (r = 0.40, p = 0.005) and post-prandial (r = 0.46, p < 0.001) conditions. In a multivariate model, post-prandial PYY concentrations were a significant predictor of ad libitum energy intake in all subjects (B±SE, −87.5 ± 34.9 kcal, p = 0.01) and in patients with PD (B±SE, −106.8 ± 44.9 kcal, p = 0.04).
PYY and GLP-1 appeared to influence appetite control in PD patients and their roles merit further investigation.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>39491667</pmid><doi>10.1016/j.clnesp.2024.10.167</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5515-0944</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Aged, 80 and over Appetite Appetite Regulation Biomarkers Biomarkers - blood Blood Glucose - metabolism Case-Control Studies Cognitive Dysfunction - blood Cognitive function Energy Intake Fasting Female Ghrelin - blood GLP-1 Glucagon-Like Peptide 1 - blood Humans Insulin - blood Leptin - blood Male Parkinson disease Parkinson Disease - blood Peptide YY - blood Postprandial Period PYY |
| title | Metabolic biomarkers of appetite control in Parkinson's disease patients with and without cognitive impairment |
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