Caveolin-1 ameliorates hepatic injury in non-alcoholic fatty liver disease by inhibiting ferroptosis via the NOX4/ROS/GPX4 pathway

[Display omitted] Nonalcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease globally, with a complex and contentious pathogenesis. Caveolin-1 (CAV1) is an important regulator of liver function and can mitigate liver injury by scavenging reactive oxygen species (ROS). Evide...

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Veröffentlicht in:	Biochemical pharmacology 2024-12, Vol.230 (Pt 2), p.116594, Article 116594
Hauptverfasser:	Wu, Shuai, Guo, Ning, Xu, Hanlin, Li, Yu, Sun, Tianyin, Jiang, Xiangfu, Fu, Dongdong, You, Tingyu, Diao, Shaoxi, Huang, Yan, Hu, Chengmu
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caveolin 1 - genetics Caveolin 1 - metabolism Caveolin-1 Cell Line Diet, High-Fat - adverse effects Ferroptosis Ferroptosis - drug effects Ferroptosis - physiology Lipid deposition Liver - drug effects Liver - metabolism Liver - pathology Male Mice Mice, Inbred C57BL NADPH Oxidase 4 - antagonists & inhibitors NADPH Oxidase 4 - genetics NADPH Oxidase 4 - metabolism Non-alcoholic fatty liver disease Non-alcoholic Fatty Liver Disease - metabolism Non-alcoholic Fatty Liver Disease - pathology NOX4/ROS/GPX4 Oxidative stress Phospholipid Hydroperoxide Glutathione Peroxidase - genetics Phospholipid Hydroperoxide Glutathione Peroxidase - metabolism Reactive Oxygen Species - metabolism Signal Transduction - drug effects Signal Transduction - physiology
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