Impaired stemness in aging periodontal ligament stem cells is mediated by the progerin/endoplasmic reticulum stress/p53 axis

[Display omitted] •This study discovered the important role of ER stress activation and p53/p21 axis in decreased stemness of aging PDLSCs, and demonstrated that ATF6-mediated ER stress response was primarily involved in this regulatory effect.•This study found progerin accumulation in PDLSCs during...

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Veröffentlicht in:	Journal of advanced research 2024-10
Hauptverfasser:	Zhang, Xige, Wang, Yazheng, Wang, Jinjin, Zhang, Yang, Li, Rui, Wang, Xiaoyu, Ge, Xiaotong, Ye, Qingyuan, Ji, Jiyun, Fei, Dongdong, Wang, Qintao
Format:	Artikel
Sprache:	eng
Schlagworte:	aging process ER stress periodontal ligament stem cells progerin stemness
Online-Zugang:	Volltext
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