Repurposing Aprepitant: Can it protect against doxorubicin-induced Chemobrain beyond its antiemetic role?

The substance P (SP) and neurokinin-1 receptor (NK-1R) axis is crucial in numerous pathological processes, including inflammation, stress responses, pain perception, and vomiting. Consequently, aprepitant, an NK-1R blocker, is used as an antiemetic in chemotherapy, including the use of doxorubicin (...

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Veröffentlicht in:	Life sciences (1973) 2024-12, Vol.359, p.123210, Article 123210
Hauptverfasser:	Gomaa, Asmaa A., Abdallah, Dalaal M., El-Abhar, Hanan S., El-Mokadem, Bassant M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiemetics - pharmacology Apoptosis - drug effects Aprepitant Aprepitant - pharmacology Chemotherapy-Related Cognitive Impairment - drug therapy Chemotherapy-Related Cognitive Impairment - metabolism Cognitive dysfunction Doxorubicin - adverse effects Doxorubicin - toxicity Drug Repositioning ER stress Hippocampus - drug effects Hippocampus - metabolism Male miR-146a Neuroprotective Agents - pharmacology PERK/eIF-2α/ATF-4/CHOP Rats Rats, Wistar Substance P Substance P - metabolism
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