Inhibition of RNA splicing triggers CHMP7 nuclear entry, impacting TDP-43 function and leading to the onset of ALS cellular phenotypes

Amyotrophic lateral sclerosis (ALS) is linked to the reduction of certain nucleoporins in neurons. Increased nuclear localization of charged multivesicular body protein 7 (CHMP7), a protein involved in nuclear pore surveillance, has been identified as a key factor damaging nuclear pores and disrupti...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Neuron (Cambridge, Mass.) Mass.), 2024-12, Vol.112 (24), p.4033-4047.e8
Hauptverfasser:	Al-Azzam, Norah, To, Jenny H., Gautam, Vaishali, Street, Lena A., Nguyen, Chloe B., Naritomi, Jack T., Lam, Dylan C., Madrigal, Assael A., Lee, Benjamin, Jin, Wenhao, Avina, Anthony, Mizrahi, Orel, Mueller, Jasmine R., Ford, Willard, Schiavon, Cara R., Rebollo, Elena, Vu, Anthony Q., Blue, Steven M., Madakamutil, Yashwin L., Manor, Uri, Rothstein, Jeffrey D., Coyne, Alyssa N., Jovanovic, Marko, Yeo, Gene W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus ALS amyotrophic lateral sclerosis Amyotrophic Lateral Sclerosis - genetics Amyotrophic Lateral Sclerosis - metabolism Amyotrophic Lateral Sclerosis - pathology Cell Nucleus - metabolism CHMP7 CRISPR screen DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Humans Induced Pluripotent Stem Cells - metabolism Motor Neurons - metabolism neurodegeneration Phenotype RNA Splicing RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism SmD1 SMN complex TDP-43
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!