The effect of Coix lachrymal L. seed extract on the expression of inflammation and fibrogenesis genes in human retinal pigment epithelial cells

Proliferative vitreoretinopathy (PVR) is a vision-threatening condition associated with retinal-detachment (RD), primarily caused by fibrocellular scar membrane formation. This study investigates the therapeutic potential of adlay seed extract fractions in mitigating PVR-associated pathways, focusin...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2024-12, Vol.181, p.117646, Article 117646
Hauptverfasser:	Gharegezloo, Zahra, Rezvani, Zahra, Sanie-Jahromi, Fatemeh, Namjoyan, Foroogh
Format:	Artikel
Sprache:	eng
Schlagworte:	Adlay seed extract Antioxidants - pharmacology Cell Line Cell Proliferation - drug effects Cell Survival - drug effects Epithelial Cells - drug effects Epithelial Cells - metabolism Fibrogenesis Fibrosis Gene Expression Regulation - drug effects Humans Inflammation Inflammation - drug therapy Inflammation - genetics Inflammation - pathology Oxidative stress Oxidative Stress - drug effects Plant Extracts - pharmacology Proliferative vitreoretinopathy (PVR) Retinal pigment epithelial (RPE) cells Retinal Pigment Epithelium - drug effects Retinal Pigment Epithelium - metabolism Retinal Pigment Epithelium - pathology Seeds - chemistry Vitreoretinopathy, Proliferative - drug therapy Vitreoretinopathy, Proliferative - genetics Vitreoretinopathy, Proliferative - metabolism Vitreoretinopathy, Proliferative - pathology
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