Recent advances in noncoding RNA modifications of gastrointestinal cancer
Elucidating the mechanisms underlying cancer development and proliferation is important for the development of therapeutic methods for the complete cure of cancer. In particular, the identification of diagnostic markers for early detection and new therapeutic strategies for refractory gastrointestin...
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| Veröffentlicht in: | Cancer science 2025-01, Vol.116 (1), p.8-20 |
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| creator | Hara, Tomoaki Meng, Sikun Arao, Yasuko Saito, Yoshiko Inoue, Kana Rennie, Sarah Ofusa, Ken Doki, Yuichiro Eguchi, Hidetoshi Kitagawa, Toru Ishii, Hideshi |
| description | Elucidating the mechanisms underlying cancer development and proliferation is important for the development of therapeutic methods for the complete cure of cancer. In particular, the identification of diagnostic markers for early detection and new therapeutic strategies for refractory gastrointestinal cancers are needed. Various abnormal phenomena occur in cancer cells, such as functional changes of proteins, led by genomic mutations, and changes in gene expression due to dysregulation of epigenetic regulation. This is no exception for noncoding RNA (ncRNA), which do not encode proteins. Recent reports have revealed that microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA) are deeply involved in cancer progression. These ncRNAs have attracted attention as gene expression regulatory molecules. Recent advances in technology have made it possible not only to read DNA and RNA sequences but also to study the modification state of each base. In particular, comprehensive analysis of N6‐methyladenosine (m6A) has been performed by many research groups, with multiple studies reporting that m6A modifications of specific genes are associated with cancer progression. Based on the above, this review examines how ncRNA modifications are related to cancer progression in gastrointestinal cancers such as colorectal and pancreatic cancer. We also discuss enzyme inhibitors that have been reported to have drug discovery potential targeting m6A modifications. By utilizing the new perspective of ncRNA modification, we may be able to accumulate knowledge on the molecular biology of cancer and contribute to human health through diagnosis and treatment.
Functional overview of RNA modifications. Some modifications of microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) activate and others inactivate signals that promote cancer progression. |
| doi_str_mv | 10.1111/cas.16380 |
| format | Article |
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Functional overview of RNA modifications. Some modifications of microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) activate and others inactivate signals that promote cancer progression.</description><identifier>ISSN: 1347-9032</identifier><identifier>ISSN: 1349-7006</identifier><identifier>EISSN: 1349-7006</identifier><identifier>DOI: 10.1111/cas.16380</identifier><identifier>PMID: 39487589</identifier><language>eng</language><publisher>England: John Wiley & Sons, Inc</publisher><subject>Adenosine - analogs & derivatives ; Adenosine - genetics ; Adenosine - metabolism ; Animals ; Cancer therapies ; Cell proliferation ; circRNA ; Circular RNA ; Disease Progression ; Enzyme inhibitors ; Epigenesis, Genetic ; Epigenetics ; Gastric cancer ; Gastrointestinal cancer ; Gastrointestinal Neoplasms - genetics ; Gastrointestinal Neoplasms - pathology ; Gene expression ; Gene Expression Regulation, Neoplastic ; Humans ; lncRNA ; Metastasis ; MicroRNAs ; MicroRNAs - genetics ; miRNA ; N6-methyladenosine ; Non-coding RNA ; Nucleotide sequence ; Pancreatic cancer ; Proteins ; Review ; RNA modification ; RNA modifications ; RNA, Circular - genetics ; RNA, Long Noncoding - genetics ; RNA, Untranslated - genetics ; Tumors</subject><ispartof>Cancer science, 2025-01, Vol.116 (1), p.8-20</ispartof><rights>2024 The Author(s). published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.</rights><rights>2024 The Author(s). Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association.</rights><rights>2025. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3430-963343647c47faf1a2075ff917b56353cb8309081bbe3b6a6a6f465c70e45b43</cites><orcidid>0000-0002-0632-6517 ; 0000-0002-2318-1129</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711047/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11711047/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,1416,11560,27922,27923,45572,45573,46050,46474,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39487589$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hara, Tomoaki</creatorcontrib><creatorcontrib>Meng, Sikun</creatorcontrib><creatorcontrib>Arao, Yasuko</creatorcontrib><creatorcontrib>Saito, Yoshiko</creatorcontrib><creatorcontrib>Inoue, Kana</creatorcontrib><creatorcontrib>Rennie, Sarah</creatorcontrib><creatorcontrib>Ofusa, Ken</creatorcontrib><creatorcontrib>Doki, Yuichiro</creatorcontrib><creatorcontrib>Eguchi, Hidetoshi</creatorcontrib><creatorcontrib>Kitagawa, Toru</creatorcontrib><creatorcontrib>Ishii, Hideshi</creatorcontrib><title>Recent advances in noncoding RNA modifications of gastrointestinal cancer</title><title>Cancer science</title><addtitle>Cancer Sci</addtitle><description>Elucidating the mechanisms underlying cancer development and proliferation is important for the development of therapeutic methods for the complete cure of cancer. In particular, the identification of diagnostic markers for early detection and new therapeutic strategies for refractory gastrointestinal cancers are needed. Various abnormal phenomena occur in cancer cells, such as functional changes of proteins, led by genomic mutations, and changes in gene expression due to dysregulation of epigenetic regulation. This is no exception for noncoding RNA (ncRNA), which do not encode proteins. Recent reports have revealed that microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA) are deeply involved in cancer progression. These ncRNAs have attracted attention as gene expression regulatory molecules. Recent advances in technology have made it possible not only to read DNA and RNA sequences but also to study the modification state of each base. In particular, comprehensive analysis of N6‐methyladenosine (m6A) has been performed by many research groups, with multiple studies reporting that m6A modifications of specific genes are associated with cancer progression. Based on the above, this review examines how ncRNA modifications are related to cancer progression in gastrointestinal cancers such as colorectal and pancreatic cancer. We also discuss enzyme inhibitors that have been reported to have drug discovery potential targeting m6A modifications. By utilizing the new perspective of ncRNA modification, we may be able to accumulate knowledge on the molecular biology of cancer and contribute to human health through diagnosis and treatment.
Functional overview of RNA modifications. 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In particular, the identification of diagnostic markers for early detection and new therapeutic strategies for refractory gastrointestinal cancers are needed. Various abnormal phenomena occur in cancer cells, such as functional changes of proteins, led by genomic mutations, and changes in gene expression due to dysregulation of epigenetic regulation. This is no exception for noncoding RNA (ncRNA), which do not encode proteins. Recent reports have revealed that microRNA (miRNA), long noncoding RNA (lncRNA), and circular RNA (circRNA) are deeply involved in cancer progression. These ncRNAs have attracted attention as gene expression regulatory molecules. Recent advances in technology have made it possible not only to read DNA and RNA sequences but also to study the modification state of each base. In particular, comprehensive analysis of N6‐methyladenosine (m6A) has been performed by many research groups, with multiple studies reporting that m6A modifications of specific genes are associated with cancer progression. Based on the above, this review examines how ncRNA modifications are related to cancer progression in gastrointestinal cancers such as colorectal and pancreatic cancer. We also discuss enzyme inhibitors that have been reported to have drug discovery potential targeting m6A modifications. By utilizing the new perspective of ncRNA modification, we may be able to accumulate knowledge on the molecular biology of cancer and contribute to human health through diagnosis and treatment.
Functional overview of RNA modifications. Some modifications of microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs) activate and others inactivate signals that promote cancer progression.</abstract><cop>England</cop><pub>John Wiley & Sons, Inc</pub><pmid>39487589</pmid><doi>10.1111/cas.16380</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0002-0632-6517</orcidid><orcidid>https://orcid.org/0000-0002-2318-1129</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adenosine - analogs & derivatives Adenosine - genetics Adenosine - metabolism Animals Cancer therapies Cell proliferation circRNA Circular RNA Disease Progression Enzyme inhibitors Epigenesis, Genetic Epigenetics Gastric cancer Gastrointestinal cancer Gastrointestinal Neoplasms - genetics Gastrointestinal Neoplasms - pathology Gene expression Gene Expression Regulation, Neoplastic Humans lncRNA Metastasis MicroRNAs MicroRNAs - genetics miRNA N6-methyladenosine Non-coding RNA Nucleotide sequence Pancreatic cancer Proteins Review RNA modification RNA modifications RNA, Circular - genetics RNA, Long Noncoding - genetics RNA, Untranslated - genetics Tumors |
| title | Recent advances in noncoding RNA modifications of gastrointestinal cancer |
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