Blood-Based Nanoparticle-Enhanced Quaking-Induced Conversion (Nano-QuIC): Inhibitor-Resistant Detection of Seeding Activity in Patients Diagnosed with Parkinson’s Disease

A hallmark of α-synucleinopathies (e.g., Parkinson’s disease) is the misfolding and aggregation of α-synuclein in tissues and biological fluids. Protein amplification assays like real-time quaking-induced conversion (RT-QuIC) are sensitive yet currently limited to semi-invasive sample types such as...

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Veröffentlicht in:	Nano letters 2024-11, Vol.24 (47), p.15016-15024
Hauptverfasser:	Christenson, Peter R., Jeong, Hyeonjeong, Li, Manci, Ahn, Hyerim, Schmeichel, Ann M., Misra, Pinaki, Li, Danni, Savica, Rodolfo, Low, Phillip A., Singer, Wolfgang, Larsen, Peter A., Park, Hye Yoon, Oh, Sang-Hyun
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Synuclein - antagonists & inhibitors alpha-Synuclein - blood Humans Nanoparticles - chemistry Parkinson Disease - blood Parkinson Disease - drug therapy
Online-Zugang:	Volltext
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