Excessive MYC-topoisome activity triggers acute DNA damage, MYC degradation, and replacement by a p53-topoisome

Hyperproliferation driven by the protooncogene MYC may lead to tumor suppressor p53 activating DNA damage that has been presumed to derive from hypertranscription and over-replication. Here, we report that excessive MYC-topoisome (MYC/topoisomerase 1/topoisomerase 2) activity acutely damages DNA-act...

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Veröffentlicht in:	Molecular cell 2024-11, Vol.84 (21), p.4059-4078.e10
Hauptverfasser:	Das, Subhendu K., Karmakar, Sharmistha, Venkatachalapathy, Harish, Jha, Rajiv Kumar, Batchelor, Eric, Levens, David
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Proliferation DNA Damage DNA repair DNA Topoisomerases, Type I - genetics DNA Topoisomerases, Type I - metabolism DNA Topoisomerases, Type II - genetics DNA Topoisomerases, Type II - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Humans Mice MYC-topoisome p53 Poly-ADP-Ribose Binding Proteins - genetics Poly-ADP-Ribose Binding Proteins - metabolism Proteolysis Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism supercoiling topoisomerase Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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