How the extra X chromosome impairs the development of male fetal germ cells

The dosage of X-linked genes is accurately regulated with the development of fetal germ cells (FGCs) 1 , 2 . How aberrant dosage of X-linked genes impairs FGC development in humans remains poorly understood. FGCs of patients with Klinefelter syndrome (KS), who have an extra X chromosome, provide nat...

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Veröffentlicht in:	Nature (London) 2024-11, Vol.635 (8040), p.960-968
Hauptverfasser:	Lu, Yongjie, Qin, Meng, He, Qilong, Hua, Lingyue, Qi, Xintong, Yang, Ming, Guo, Qianying, Liu, Xixi, Zhang, Zhe, Xu, Fanqing, Ding, Ling, Wu, Yixuan, Zhang, Cong, Zhai, Fan, Liu, Qiang, Li, Jiaxin, Yuan, Pengbo, Shi, Xiaoming, Wang, Xueju, Zhao, Cheng, Lian, Ying, Li, Rong, Wei, Yuan, Yan, Liying, Yuan, Peng, Qiao, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	13/106 38/1 38/23 38/32 38/39 38/91 631/136/1425 631/532/1519 Animals Cell Differentiation - genetics Cell Movement Chromosomes, Human, X - genetics Female Fetus - cytology Fetus - embryology Fetus - metabolism Gene Dosage - genetics Gene Expression Regulation, Developmental Genes, X-Linked - genetics Germ Cells - cytology Germ Cells - metabolism Germ Cells - pathology Humanities and Social Sciences Humans Klinefelter Syndrome - genetics Klinefelter Syndrome - metabolism Klinefelter Syndrome - pathology Male Models, Biological multidisciplinary Science Science (multidisciplinary) Sertoli Cells - cytology Sertoli Cells - metabolism Sertoli Cells - pathology Sex Characteristics Transforming Growth Factor beta - metabolism Wnt Signaling Pathway - genetics
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