The AKR1C1-CYP1B1-cAMP signaling axis controls tumorigenicity and ferroptosis susceptibility of extrahepatic cholangiocarcinoma

Extrahepatic cholangiocarcinoma (ECC), a highly malignant type of cancer with increasing incidence, has a poor prognosis due to limited treatment options. Based on genomic analysis of ECC patient samples, here we report that aldo-keto reductase family 1 member C1 (AKR1C1) is highly expressed in huma...

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Veröffentlicht in:Cell death and differentiation 2024-10
Hauptverfasser: Liu, Chang, Zhang, Cheng, Wu, Hongkun, Zhao, Zhibin, Wang, Zhenhua, Zhang, Xiaomin, Yang, Jieli, Yu, Wenlong, Lian, Zhexiong, Gao, Minghui, Zhou, Lin
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Sprache:eng
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