Formononetin Induces Ferroptosis in Activated Hepatic Stellate Cells to Attenuate Liver Fibrosis by Targeting NADPH Oxidase 4

ABSTRACT Ferroptosis is a newly discovered type of cell death that exerts a crucial role in hepatic fibrosis. Formononetin (FMN), a natural isoflavone compound mainly isolated from Spatholobus suberectus Dunn, shows multiple biological activities, including antioxidant, anti‐inflammatory, and hepato...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Phytotherapy research 2024-12, Vol.38 (12), p.5988-6003
Hauptverfasser:	Liu, Ming‐xuan, Gu, Ying‐ying, Nie, Wen‐yuan, Zhu, Xiao‐ming, Qi, Meng‐jing, Zhao, Rui‐min, Zhu, Wei‐zhong, Zhang, Xiao‐ling
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylcysteine Amino acids Animals Calorimetry Carbon Tetrachloride Cell death Chemical synthesis Deferoxamine Deferoxamine - pharmacology Ferroptosis Ferroptosis - drug effects Fibrosis formononetin Hepatic Stellate Cells - drug effects Hepatic Stellate Cells - metabolism Hepatocytes Isoflavones - pharmacology Liver Liver cirrhosis Liver Cirrhosis - chemically induced Liver Cirrhosis - drug therapy liver fibrosis Male NAD(P)H oxidase NADPH Oxidase 4 - metabolism NADPH oxidases 4 NOX4 protein Oxidase Protons Rats Rats, Sprague-Dawley reactive oxygen species Regulatory mechanisms (biology) Stellate cells Surface plasmon resonance Titration Titration calorimetry
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!