Fatty acid amide hydrolase gene inactivation induces hetero‐cellular potentiation of microglial function in the 5xFAD mouse model of Alzheimer's disease

Neuroinflammation has recently emerged as a crucial factor in Alzheimer's disease (AD) etiopathogenesis. Microglial cells play an important function in the inflammatory response; specifically, the emergence of disease‐associated microglia (DAM) has offered new insights into the conflicting pers...

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Veröffentlicht in:	Glia 2025-02, Vol.73 (2), p.352-367
Hauptverfasser:	Arnanz, María Andrea, Ferrer, María, Grande, María Teresa, Martín Esteban, Samuel Ruiz, Ruiz‐Pérez, Gonzalo, Cravatt, Benjamin F., Mostany, Ricardo, Lobo, Víctor Javier Sánchez‐Arévalo, Romero, Julián, Martínez‐Relimpio, Ana María
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer's disease Amidohydrolases - genetics Amidohydrolases - metabolism Amyloid beta-Peptides - metabolism Amyloidosis Animals Central nervous system damage associated microglia Deactivation Disease Models, Animal Fatty acids Fatty-acid amide hydrolase Gene expression Gene sequencing Genes In vivo methods and tests Inactivation Inflammatory response Mice Mice, Inbred C57BL Mice, Transgenic Microglia Microglia - metabolism Microglia - pathology Morphology Neurodegenerative diseases neuroinflammation Plaque, Amyloid - genetics Plaque, Amyloid - metabolism Plaque, Amyloid - pathology Sequence analysis Therapeutic targets two‐photon microscopy β-Amyloid
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