The role of ischaemia-modified albumin in the prognosis of acute pancreatitis and its correlation with the NF-κB-mediated inflammatory response
Objective To investigate the correlation between the serum levels of ischaemia-modified albumin (IMA) and disease severity in rats with acute pancreatitis (AP). Methods A rat AP model was established and blood samples from each group were analysed at different time points. After the experiment, the...
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| Veröffentlicht in: | Journal of international medical research 2024-10, Vol.52 (10), p.3000605241287163 |
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| creator | Geng, Cheng Zhang, Junxiang Wu, Shixing Zhang, Bolin Tian, Xinxin A, Tigu Su, Hongde Xu, Xinjian |
| description | Objective
To investigate the correlation between the serum levels of ischaemia-modified albumin (IMA) and disease severity in rats with acute pancreatitis (AP).
Methods
A rat AP model was established and blood samples from each group were analysed at different time points. After the experiment, the pancreatic tissues of the rats were collected for pathological examination and the measurement of protein levels of NF-κB and NF-κB p65. Serum levels of amylase (α-AMY), tumour necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-8 were also compared between groups of rats.
Results
The serum IMA concentration in the severe acute pancreatitis (SAP) group was greater than that in the mild acute pancreatitis (MAP) group. The levels of the NF-κB and NF-κB p65 proteins were increased in the MAP and SAP groups in a time-dependent manner. α-AMY, TNF-α and IL-6 were increased at all time points in the MAP and SAP groups. The increases were greatest at 24 h in the SAP group. In terms of pathological changes in the pancreas, renal and lung tissues, the damage in the SAP group was more obvious than that in the MAP group.
Conclusions
Serum IMA level was associated with inflammatory markers and NF-κB p65 in rats with AP. |
| doi_str_mv | 10.1177/03000605241287163 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3122633025</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sage_id>10.1177_03000605241287163</sage_id><sourcerecordid>3122633025</sourcerecordid><originalsourceid>FETCH-LOGICAL-c250t-957bbf38bedd5bc9172c2f9de3fe07fbc9311e8eca35b279c1dfb12e59cac5d93</originalsourceid><addsrcrecordid>eNp1kc9KHTEUxoNY6q3tA3RTAm7cjObPZHJn2V7UFkQ3dj1kkhNvZCa5JhnEt_B5fAifyUyvtWARAoHv_M53cvIh9JWSI0qlPCacENIQwWrKlpI2fActaC15xUphFy3mejUDe-hTSjeE1KwR7CPa420t66YWC_RwtQYcwwA4WOySXisYnarGYJx1YLAa-ml0HpeTC7mJ4dqH5NKMKz3lIimvI6jsclGVN9jlhHWIEYYiBo_vXF7_ab44rZ4ef1QjGKdy8XbeDmocVQ7xHkdIm-ATfEYfrBoSfHm599Hv05Or1c_q_PLs1-r7eaWZILlqhex7y5c9GCN63VLJNLOtAW6BSFsUTiksQSsueiZbTY3tKQPRaqWFafk-Otz6lpVuJ0i5G8v6MAzKQ5hSxyljDeeEiYIevEFvwhR9ed1M1VQwyXih6JbSMaQUwXab6EYV7ztKujmu7r-4Ss-3F-epL9_y2vE3nwIcbYGkruHf2PcdnwGo2qAa</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3124152723</pqid></control><display><type>article</type><title>The role of ischaemia-modified albumin in the prognosis of acute pancreatitis and its correlation with the NF-κB-mediated inflammatory response</title><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>Sage Journals GOLD Open Access 2024</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Geng, Cheng ; Zhang, Junxiang ; Wu, Shixing ; Zhang, Bolin ; Tian, Xinxin ; A, Tigu ; Su, Hongde ; Xu, Xinjian</creator><creatorcontrib>Geng, Cheng ; Zhang, Junxiang ; Wu, Shixing ; Zhang, Bolin ; Tian, Xinxin ; A, Tigu ; Su, Hongde ; Xu, Xinjian</creatorcontrib><description>Objective
To investigate the correlation between the serum levels of ischaemia-modified albumin (IMA) and disease severity in rats with acute pancreatitis (AP).
Methods
A rat AP model was established and blood samples from each group were analysed at different time points. After the experiment, the pancreatic tissues of the rats were collected for pathological examination and the measurement of protein levels of NF-κB and NF-κB p65. Serum levels of amylase (α-AMY), tumour necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-8 were also compared between groups of rats.
Results
The serum IMA concentration in the severe acute pancreatitis (SAP) group was greater than that in the mild acute pancreatitis (MAP) group. The levels of the NF-κB and NF-κB p65 proteins were increased in the MAP and SAP groups in a time-dependent manner. α-AMY, TNF-α and IL-6 were increased at all time points in the MAP and SAP groups. The increases were greatest at 24 h in the SAP group. In terms of pathological changes in the pancreas, renal and lung tissues, the damage in the SAP group was more obvious than that in the MAP group.
Conclusions
Serum IMA level was associated with inflammatory markers and NF-κB p65 in rats with AP.</description><identifier>ISSN: 0300-0605</identifier><identifier>ISSN: 1473-2300</identifier><identifier>EISSN: 1473-2300</identifier><identifier>DOI: 10.1177/03000605241287163</identifier><identifier>PMID: 39474645</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Acute Disease ; Amylases - blood ; Animals ; Biomarkers - blood ; Disease Models, Animal ; Inflammation - blood ; Inflammation - metabolism ; Inflammation - pathology ; Interleukin-6 - blood ; Interleukin-8 - blood ; Ischemia ; Male ; NF-kappa B - metabolism ; Pancreas - metabolism ; Pancreas - pathology ; Pancreatitis ; Pancreatitis - blood ; Pancreatitis - diagnosis ; Pancreatitis - metabolism ; Pancreatitis - pathology ; Prognosis ; Rats ; Rats, Sprague-Dawley ; Serum Albumin - analysis ; Serum Albumin - metabolism ; Serum Albumin, Human - metabolism ; Transcription Factor RelA - metabolism ; Tumor Necrosis Factor-alpha - blood ; Tumor necrosis factor-TNF</subject><ispartof>Journal of international medical research, 2024-10, Vol.52 (10), p.3000605241287163</ispartof><rights>The Author(s) 2024</rights><rights>The Author(s) 2024. This work is licensed under the Creative Commons Attribution – Non-Commercial License https://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c250t-957bbf38bedd5bc9172c2f9de3fe07fbc9311e8eca35b279c1dfb12e59cac5d93</cites><orcidid>0009-0008-1290-2120</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.sagepub.com/doi/pdf/10.1177/03000605241287163$$EPDF$$P50$$Gsage$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://journals.sagepub.com/doi/10.1177/03000605241287163$$EHTML$$P50$$Gsage$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,864,21964,27851,27922,27923,44943,45331</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39474645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Geng, Cheng</creatorcontrib><creatorcontrib>Zhang, Junxiang</creatorcontrib><creatorcontrib>Wu, Shixing</creatorcontrib><creatorcontrib>Zhang, Bolin</creatorcontrib><creatorcontrib>Tian, Xinxin</creatorcontrib><creatorcontrib>A, Tigu</creatorcontrib><creatorcontrib>Su, Hongde</creatorcontrib><creatorcontrib>Xu, Xinjian</creatorcontrib><title>The role of ischaemia-modified albumin in the prognosis of acute pancreatitis and its correlation with the NF-κB-mediated inflammatory response</title><title>Journal of international medical research</title><addtitle>J Int Med Res</addtitle><description>Objective
To investigate the correlation between the serum levels of ischaemia-modified albumin (IMA) and disease severity in rats with acute pancreatitis (AP).
Methods
A rat AP model was established and blood samples from each group were analysed at different time points. After the experiment, the pancreatic tissues of the rats were collected for pathological examination and the measurement of protein levels of NF-κB and NF-κB p65. Serum levels of amylase (α-AMY), tumour necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-8 were also compared between groups of rats.
Results
The serum IMA concentration in the severe acute pancreatitis (SAP) group was greater than that in the mild acute pancreatitis (MAP) group. The levels of the NF-κB and NF-κB p65 proteins were increased in the MAP and SAP groups in a time-dependent manner. α-AMY, TNF-α and IL-6 were increased at all time points in the MAP and SAP groups. The increases were greatest at 24 h in the SAP group. In terms of pathological changes in the pancreas, renal and lung tissues, the damage in the SAP group was more obvious than that in the MAP group.
Conclusions
Serum IMA level was associated with inflammatory markers and NF-κB p65 in rats with AP.</description><subject>Acute Disease</subject><subject>Amylases - blood</subject><subject>Animals</subject><subject>Biomarkers - blood</subject><subject>Disease Models, Animal</subject><subject>Inflammation - blood</subject><subject>Inflammation - metabolism</subject><subject>Inflammation - pathology</subject><subject>Interleukin-6 - blood</subject><subject>Interleukin-8 - blood</subject><subject>Ischemia</subject><subject>Male</subject><subject>NF-kappa B - metabolism</subject><subject>Pancreas - metabolism</subject><subject>Pancreas - pathology</subject><subject>Pancreatitis</subject><subject>Pancreatitis - blood</subject><subject>Pancreatitis - diagnosis</subject><subject>Pancreatitis - metabolism</subject><subject>Pancreatitis - pathology</subject><subject>Prognosis</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Serum Albumin - analysis</subject><subject>Serum Albumin - metabolism</subject><subject>Serum Albumin, Human - metabolism</subject><subject>Transcription Factor RelA - metabolism</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Tumor necrosis factor-TNF</subject><issn>0300-0605</issn><issn>1473-2300</issn><issn>1473-2300</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>AFRWT</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp1kc9KHTEUxoNY6q3tA3RTAm7cjObPZHJn2V7UFkQ3dj1kkhNvZCa5JhnEt_B5fAifyUyvtWARAoHv_M53cvIh9JWSI0qlPCacENIQwWrKlpI2fActaC15xUphFy3mejUDe-hTSjeE1KwR7CPa420t66YWC_RwtQYcwwA4WOySXisYnarGYJx1YLAa-ml0HpeTC7mJ4dqH5NKMKz3lIimvI6jsclGVN9jlhHWIEYYiBo_vXF7_ab44rZ4ef1QjGKdy8XbeDmocVQ7xHkdIm-ATfEYfrBoSfHm599Hv05Or1c_q_PLs1-r7eaWZILlqhex7y5c9GCN63VLJNLOtAW6BSFsUTiksQSsueiZbTY3tKQPRaqWFafk-Otz6lpVuJ0i5G8v6MAzKQ5hSxyljDeeEiYIevEFvwhR9ed1M1VQwyXih6JbSMaQUwXab6EYV7ztKujmu7r-4Ss-3F-epL9_y2vE3nwIcbYGkruHf2PcdnwGo2qAa</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>Geng, Cheng</creator><creator>Zhang, Junxiang</creator><creator>Wu, Shixing</creator><creator>Zhang, Bolin</creator><creator>Tian, Xinxin</creator><creator>A, Tigu</creator><creator>Su, Hongde</creator><creator>Xu, Xinjian</creator><general>SAGE Publications</general><general>Sage Publications Ltd</general><scope>AFRWT</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0008-1290-2120</orcidid></search><sort><creationdate>202410</creationdate><title>The role of ischaemia-modified albumin in the prognosis of acute pancreatitis and its correlation with the NF-κB-mediated inflammatory response</title><author>Geng, Cheng ; Zhang, Junxiang ; Wu, Shixing ; Zhang, Bolin ; Tian, Xinxin ; A, Tigu ; Su, Hongde ; Xu, Xinjian</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c250t-957bbf38bedd5bc9172c2f9de3fe07fbc9311e8eca35b279c1dfb12e59cac5d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acute Disease</topic><topic>Amylases - blood</topic><topic>Animals</topic><topic>Biomarkers - blood</topic><topic>Disease Models, Animal</topic><topic>Inflammation - blood</topic><topic>Inflammation - metabolism</topic><topic>Inflammation - pathology</topic><topic>Interleukin-6 - blood</topic><topic>Interleukin-8 - blood</topic><topic>Ischemia</topic><topic>Male</topic><topic>NF-kappa B - metabolism</topic><topic>Pancreas - metabolism</topic><topic>Pancreas - pathology</topic><topic>Pancreatitis</topic><topic>Pancreatitis - blood</topic><topic>Pancreatitis - diagnosis</topic><topic>Pancreatitis - metabolism</topic><topic>Pancreatitis - pathology</topic><topic>Prognosis</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Serum Albumin - analysis</topic><topic>Serum Albumin - metabolism</topic><topic>Serum Albumin, Human - metabolism</topic><topic>Transcription Factor RelA - metabolism</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Geng, Cheng</creatorcontrib><creatorcontrib>Zhang, Junxiang</creatorcontrib><creatorcontrib>Wu, Shixing</creatorcontrib><creatorcontrib>Zhang, Bolin</creatorcontrib><creatorcontrib>Tian, Xinxin</creatorcontrib><creatorcontrib>A, Tigu</creatorcontrib><creatorcontrib>Su, Hongde</creatorcontrib><creatorcontrib>Xu, Xinjian</creatorcontrib><collection>Sage Journals GOLD Open Access 2024</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of international medical research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Geng, Cheng</au><au>Zhang, Junxiang</au><au>Wu, Shixing</au><au>Zhang, Bolin</au><au>Tian, Xinxin</au><au>A, Tigu</au><au>Su, Hongde</au><au>Xu, Xinjian</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of ischaemia-modified albumin in the prognosis of acute pancreatitis and its correlation with the NF-κB-mediated inflammatory response</atitle><jtitle>Journal of international medical research</jtitle><addtitle>J Int Med Res</addtitle><date>2024-10</date><risdate>2024</risdate><volume>52</volume><issue>10</issue><spage>3000605241287163</spage><pages>3000605241287163-</pages><issn>0300-0605</issn><issn>1473-2300</issn><eissn>1473-2300</eissn><abstract>Objective
To investigate the correlation between the serum levels of ischaemia-modified albumin (IMA) and disease severity in rats with acute pancreatitis (AP).
Methods
A rat AP model was established and blood samples from each group were analysed at different time points. After the experiment, the pancreatic tissues of the rats were collected for pathological examination and the measurement of protein levels of NF-κB and NF-κB p65. Serum levels of amylase (α-AMY), tumour necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-8 were also compared between groups of rats.
Results
The serum IMA concentration in the severe acute pancreatitis (SAP) group was greater than that in the mild acute pancreatitis (MAP) group. The levels of the NF-κB and NF-κB p65 proteins were increased in the MAP and SAP groups in a time-dependent manner. α-AMY, TNF-α and IL-6 were increased at all time points in the MAP and SAP groups. The increases were greatest at 24 h in the SAP group. In terms of pathological changes in the pancreas, renal and lung tissues, the damage in the SAP group was more obvious than that in the MAP group.
Conclusions
Serum IMA level was associated with inflammatory markers and NF-κB p65 in rats with AP.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>39474645</pmid><doi>10.1177/03000605241287163</doi><orcidid>https://orcid.org/0009-0008-1290-2120</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Sage Journals GOLD Open Access 2024; PubMed Central; Alma/SFX Local Collection |
| subjects | Acute Disease Amylases - blood Animals Biomarkers - blood Disease Models, Animal Inflammation - blood Inflammation - metabolism Inflammation - pathology Interleukin-6 - blood Interleukin-8 - blood Ischemia Male NF-kappa B - metabolism Pancreas - metabolism Pancreas - pathology Pancreatitis Pancreatitis - blood Pancreatitis - diagnosis Pancreatitis - metabolism Pancreatitis - pathology Prognosis Rats Rats, Sprague-Dawley Serum Albumin - analysis Serum Albumin - metabolism Serum Albumin, Human - metabolism Transcription Factor RelA - metabolism Tumor Necrosis Factor-alpha - blood Tumor necrosis factor-TNF |
| title | The role of ischaemia-modified albumin in the prognosis of acute pancreatitis and its correlation with the NF-κB-mediated inflammatory response |
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