Design, synthesis, and pharmacological characterization of sulfonylurea-based NLRP3 inhibitors: Towards an effective therapeutic strategy for Alzheimer's disease

Alzheimer's disease (AD) is a prevalent neurodegenerative disorder that severely diminishes the quality of life for millions. The NLRP3 inflammasome, a critical mediator of inflammation, has emerged as a promising therapeutic target for AD. In this study, we report the development and optimizat...

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Veröffentlicht in:	European journal of medicinal chemistry 2024-12, Vol.280, p.116993, Article 116993
Hauptverfasser:	Lyu, Weiping, Gao, Tongfei, Shi, Cheng, Lu, Dehua, Chen, Yanming, Qin, Haoming, Yu, Ruohan, Zhang, Huiying, Zhou, Xiaonan, Qiang, Bo, Chen, Qixuan, Liu, Yiqiao, Song, Song, Chen, Qing, Zhang, Liangren, Liu, Zhenming
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer's disease Animals Cognitive Dysfunction Dose-Response Relationship, Drug Drug Design Humans Male Mice Mice, Inbred C57BL Molecular Structure Neuroinflammation NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 inhibition Structure-Activity Relationship Sulfonylurea Compounds - chemical synthesis Sulfonylurea Compounds - chemistry Sulfonylurea Compounds - pharmacology Sulfonylurea Compounds - therapeutic use Sulfonylurea derivatives
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