Perturbation-specific transcriptional mapping for unbiased target elucidation of antibiotics

The rising prevalence of antibiotic resistance threatens human health. While more sophisticated strategies for antibiotic discovery are being developed, target elucidation of new chemical entities remains challenging. In the postgenomic era, expression profiling can play an important role in mechani...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2024-11, Vol.121 (45), p.e2409747121
Hauptverfasser:	Romano, Keith P, Bagnall, Josephine, Warrier, Thulasi, Sullivan, Jaryd, Ferrara, Kristina, Orzechowski, Marek, Nguyen, Phuong H, Raines, Kyra, Livny, Jonathan, Shoresh, Noam, Hung, Deborah T
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - pharmacology Antibiotic resistance Antibiotics Chemical activity CRISPR Depletion Drug Discovery - methods Gene Expression Profiling - methods Gene Expression Regulation, Bacterial - drug effects Humans Mapping Microbial Sensitivity Tests Perturbation Predictions Pseudomonas aeruginosa - drug effects Pseudomonas aeruginosa - genetics Transcription Transcription, Genetic - drug effects Transcriptome Transcriptomics
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