Allosteric inhibition of the tyrosine phosphatase SHP2 enhances the anti-tumor immunity of interferon α through induction of caspase-1-mediated pyroptosis in renal cancer

[Display omitted] •SHP099 enhances the anti-proliferative effect of IFNα on RCC in vitro and in vivo.•SHP099 stimulates caspase-1 expression by activating NF-κB signaling.•SHP099 stimulates NLRP3 inflammasome activation via mitochondrial ANT1.•SHP099 enhances anti-tumor immunity induced by IFNα in v...

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Veröffentlicht in:	International immunopharmacology 2024-12, Vol.143 (Pt 2), p.113498, Article 113498
Hauptverfasser:	Xi, Ruiying, Cao, Yu, Fu, Naijie, Sheng, Yuwen, Yu, Jialing, Li, Lingyu, Zhang, Guolin, Wang, Fei
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation Animals Carcinoma, Renal Cell - drug therapy Carcinoma, Renal Cell - immunology Caspase 1 - metabolism Caspase-1 Cell Line, Tumor Cell Proliferation - drug effects Humans IFNα Inflammasomes - metabolism Interferon-alpha Kidney Neoplasms - drug therapy Kidney Neoplasms - immunology Kidney Neoplasms - pathology Mice Mice, Inbred C57BL NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 inflammasome Piperidines - pharmacology Protein Tyrosine Phosphatase, Non-Receptor Type 11 - metabolism Pyrimidines - pharmacology Pyroptosis Pyroptosis - drug effects SHP2
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