Tuning porosity of macroporous hydrogels enables rapid rates of stress relaxation and promotes cell expansion and migration

Extracellular matrix (ECM) viscoelasticity broadly regulates cell behavior. While hydrogels can approximate the viscoelasticity of native ECM, it remains challenging to recapitulate the rapid stress relaxation observed in many tissues without limiting the mechanical stability of the hydrogel. Here,...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS 2024-11, Vol.121 (45), p.e2410806121
Hauptverfasser: Nerger, Bryan A, Kashyap, Kirti, Deveney, Brendan T, Lou, Junzhe, Hanan, Blake F, Liu, Qi, Khalil, Andrew, Lungjangwa, Tenzin, Cheriyan, Maria, Gupta, Anupam, Jaenisch, Rudolf, Weitz, David A, Mahadevan, L, Mooney, David J
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Sprache:eng
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