The analgesic effect and mechanism of the active components screening from Corydalis yanhusuo by P2X3 receptors

Cavidine (CAV) is the main bioactive ingredient of Corydalis ternata f. yanhusuo (Y.H.Chou & Chun C.Hsu) Y.C.Zhu, which is a traditional Chinese herbal containing a variety of uses such as analgesic, anticancer, and anti-inflammatory properties. The goal is to screen Corydalis yanhusuo for anti-...

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Veröffentlicht in:	Journal of ethnopharmacology 2025-01, Vol.337 (Pt 2), p.118989, Article 118989
Hauptverfasser:	Luo, Zhenhui, Zhang, Zhenglang, Li, Peiyang, Yi, Mengqin, Luo, Anqi, Zeng, Hekun, Wang, Tingting, Wang, Junlin, Nie, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	active ingredients analgesic effect analgesics Analgesics - isolation & purification Analgesics - pharmacology Animals bioinformatics Cavidine cell membranes chromatography Chronic pain Chronic Pain - drug therapy Corydalis - chemistry Corydalis yanhusuo Disease Models, Animal Drugs, Chinese Herbal - chemistry Drugs, Chinese Herbal - pharmacology Freund's Adjuvant ganglia Ganglia, Spinal - drug effects Ganglia, Spinal - metabolism interleukin-6 Male Mice Mice, Inbred C57BL Microglia - drug effects Microglia - metabolism Microglia activation nerve tissue neuroglia P2X3 receptor pain Receptors, Purinergic P2X3 - metabolism sequence analysis spinal cord therapeutics traditional medicine vaccine adjuvants
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