Safflower yellow alleviates cognitive impairment in mice by modulating cholinergic system function, oxidative stress, and CREB/BDNF/TrkB signaling pathway

Carthamus tinctorius L. (Safflower) was believed to have multiple benefits, including antioxidant effects, enhanced learning and memory, and improving neuronal injury. Safflower Yellow(SY) are the main active ingredients of Safflower, displays strong pharmacological potential treatment of Alzheimer&...

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Veröffentlicht in:	Journal of ethnopharmacology 2025-01, Vol.340, p.118986, Article 118986
Hauptverfasser:	Qi, Yanqiang, Wang, Yanyou, Ni, Mingyue, He, Yingxi, Li, Le, Hu, Yanli
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain-Derived Neurotrophic Factor - metabolism Chalcone - analogs & derivatives Chalcone - pharmacology Cholinergic system Cognitive Dysfunction - drug therapy Cognitive Dysfunction - metabolism CREB/BDNF/TrkB pathway Cyclic AMP Response Element-Binding Protein - metabolism Disease Models, Animal Ethanol Male Maze Learning - drug effects Membrane Glycoproteins - metabolism Memory Disorders - drug therapy Mice Mice, Inbred ICR Morris Water Maze Test - drug effects NaNO2 Oxidative stress Oxidative Stress - drug effects Receptor, trkB - metabolism Scopolamine Scopolamine hydrobromide Signal Transduction - drug effects
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