Fully human monoclonal antibody targeting the cysteine-rich substrate-interacting region of ADAM17 on cancer cells

ADAM17 sheds EGFR/erbB ligands and triggers oncogenic pathways that lead to the progression of solid tumors. We targeted the ADAM17 disintegrin and cysteine rich domain region (D+C) to generate a panel of single-chain antibody fragments (scFvs) that selectively bind to the D or C domains of ADAM17,...

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Veröffentlicht in:	Biomedicine & pharmacotherapy 2024-11, Vol.180, p.117605, Article 117605
Hauptverfasser:	Saha, Nayanendu, Lee, Sang Gyu, Brockmann, Eeva-Christine, de la Cruz, M. Jason, Goldgur, Yehuda, Mendoza, Rachelle P., Stanchina, Elisa de, Love, Tanzy M., Marvald, Josh, Xu, Yan, Xu, Kai, Himanen, Juha P., Lamminmäki, Urpo, Veach, Darren, Nikolov, Dimitar B.
Format:	Artikel
Sprache:	eng
Schlagworte:	ADAM17 ADAM17 Protein - metabolism Animals Antibodies, Monoclonal - pharmacology Cell Line, Tumor Cryo-electron microscopy Cysteine - metabolism Epidermal growth factor ErbB Receptors - immunology ErbB Receptors - metabolism Female HEK293 Cells Humans Mice Mice, Nude Monoclonal antibody Neoplasms - drug therapy Neoplasms - metabolism Neoplasms - pathology Positron emission tomography Xenograft Xenograft Model Antitumor Assays
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