Dual modes of ZFC3H1 confer selectivity in nuclear RNA sorting

The export and degradation pathways compete to sort nuclear RNAs, yet the default pathway remains unclear. Sorting of mature RNAs to degradation, facilitated by the exosome co-factor poly(A) exosome targeting (PAXT), is particularly challenging for their resemblance to mRNAs intended for translation...

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Veröffentlicht in:	Molecular cell 2024-11, Vol.84 (22), p.4297-4313.e7
Hauptverfasser:	Fan, Jing, Wang, Yimin, Wen, Miaomiao, Tong, Deng, Wu, Kai, Yan, Kunming, Jia, Peixuan, Zhu, Yi, Liu, Qinyu, Zou, Hecun, Zhao, Peng, Lu, Falong, Yun, Caihong, Xue, Yuanchao, Zhou, Yu, Cheng, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Cell Nucleus - genetics Cell Nucleus - metabolism Exons Exosomes - genetics Exosomes - metabolism HEK293 Cells HeLa Cells Humans Introns nuclear export nuclear RNA sorting PAXT RNA degradation RNA Precursors - genetics RNA Precursors - metabolism RNA Stability RNA Transport RNA, Nuclear - genetics RNA, Nuclear - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism ZFC3H1
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