Advances in bacterial artificial chromosome (BAC) transgenic mice for gene analysis and disease research

•BAC transgenesis enables study of large genes with native regulatory elements.•Humanized BAC mice model human diseases and drug responses.•Position effects and copy number variation remain key challenges.•BAC mice bridge basic research and clinical applications in biomedicine. Transgenic mice, incl...

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Veröffentlicht in:	Gene 2025-01, Vol.934, p.149014, Article 149014
Hauptverfasser:	Mogi, Kazumasa, Tomita, Hiroyuki, Yoshihara, Masato, Kajiyama, Hiroaki, Hara, Akira
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacterial Artificial Chromosome (BAC) Chromosomes, Artificial, Bacterial - genetics CRISPR-Cas Systems Disease Models, Animal Genetically modified mice Humanized BAC transgenic mice Humans Mice Mice, Transgenic - genetics Pathogenesis, animal model Transgenic mouse technology
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